Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5099878..5100545 Replicon chromosome
Accession NZ_CP009007
Organism Xanthomonas citri pv. citri strain MF20

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AMD10_RS22205 Protein ID WP_005916679.1
Coordinates 5100129..5100545 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AMD10_RS22200 Protein ID WP_005916676.1
Coordinates 5099878..5100132 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD10_RS22175 5096000..5096219 + 220 Protein_4257 RNA 2'-phosphotransferase -
AMD10_RS22180 5096376..5097641 + 1266 WP_015463799.1 cardiolipin synthase B -
AMD10_RS22185 5097667..5098194 - 528 WP_005916668.1 hypothetical protein -
AMD10_RS22190 5098433..5098639 + 207 WP_003489327.1 hypothetical protein -
AMD10_RS22195 5098626..5099732 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AMD10_RS22200 5099878..5100132 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AMD10_RS22205 5100129..5100545 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AMD10_RS25070 5100667..5100879 - 213 WP_015472900.1 hypothetical protein -
AMD10_RS25075 5100998..5101210 - 213 WP_015472901.1 hypothetical protein -
AMD10_RS22210 5101467..5103086 + 1620 WP_015463800.1 hypothetical protein -
AMD10_RS22215 5103190..5103588 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AMD10_RS22220 5103904..5104335 + 432 WP_005922907.1 hypothetical protein -
AMD10_RS24565 5104364..5104690 - 327 Protein_4269 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T48060 WP_005916679.1 NZ_CP009007:5100129-5100545 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T48060 NZ_CP009007:5100129-5100545 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT48060 WP_005916676.1 NZ_CP009007:5099878-5100132 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT48060 NZ_CP009007:5099878-5100132 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References