Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5049173..5049840 Replicon chromosome
Accession NZ_CP009004
Organism Xanthomonas citri pv. citri strain MN10

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AMD16_RS22065 Protein ID WP_005916679.1
Coordinates 5049424..5049840 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AMD16_RS22060 Protein ID WP_005916676.1
Coordinates 5049173..5049427 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD16_RS22035 5045295..5045514 + 220 Protein_4200 RNA 2'-phosphotransferase -
AMD16_RS22040 5045671..5046936 + 1266 WP_015463799.1 cardiolipin synthase B -
AMD16_RS22045 5046962..5047489 - 528 WP_005916668.1 hypothetical protein -
AMD16_RS22050 5047728..5047934 + 207 WP_003489327.1 hypothetical protein -
AMD16_RS22055 5047921..5049027 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AMD16_RS22060 5049173..5049427 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AMD16_RS22065 5049424..5049840 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AMD16_RS24830 5049962..5050234 - 273 WP_129545227.1 hypothetical protein -
AMD16_RS24835 5050293..5050505 - 213 WP_015472901.1 hypothetical protein -
AMD16_RS22070 5050762..5052381 + 1620 WP_015463800.1 hypothetical protein -
AMD16_RS22075 5052485..5052883 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AMD16_RS22080 5053199..5053630 + 432 WP_005922907.1 hypothetical protein -
AMD16_RS24400 5053659..5053985 - 327 Protein_4212 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T48052 WP_005916679.1 NZ_CP009004:5049424-5049840 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T48052 NZ_CP009004:5049424-5049840 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT48052 WP_005916676.1 NZ_CP009004:5049173-5049427 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT48052 NZ_CP009004:5049173-5049427 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References