Detailed information of TA system TA048049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2549991..2550624
• Replicon: chromosome
• Accession: NZ_CP009004
• Organism: Xanthomonas citri pv. citri strain MN10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AMD16_RS11565
• Protein ID: WP_015463212.1
• Coordinates: 2549991..2550404 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: AMD16_RS11570
• Protein ID: WP_015463213.1
• Coordinates: 2550391..2550624 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AMD16_RS11555	2545683..2547863	+	2181	WP_011051394.1	TonB-dependent siderophore receptor	-
AMD16_RS11560	2548072..2549586	+	1515	WP_015463210.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
AMD16_RS23400	2549602..2549964	-	363	WP_015463211.1	DUF3742 family protein	-
AMD16_RS11565	2549991..2550404	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
AMD16_RS11570	2550391..2550624	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AMD16_RS11575	2550882..2551913	+	1032	WP_040107627.1	DUF4917 family protein	-
AMD16_RS11580	2552046..2552444	-	399	WP_099521978.1	hypothetical protein	-
AMD16_RS11585	2552896..2553471	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
AMD16_RS11590	2553452..2554501	+	1050	WP_011051401.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T48049 WP_015463212.1 NZ_CP009004:c2550404-2549991 [Xanthomonas citri pv. citri]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T48049 NZ_CP009004:c2550404-2549991 [Xanthomonas citri pv. citri]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT48049 WP_015463213.1 NZ_CP009004:c2550624-2550391 [Xanthomonas citri pv. citri]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT48049 NZ_CP009004:c2550624-2550391 [Xanthomonas citri pv. citri]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Structures

Antitoxin

• AlphaFold DB: M4TWF0