Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5049160..5049827 Replicon chromosome
Accession NZ_CP008998
Organism Xanthomonas citri pv. citri strain MN12

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AMD14_RS22065 Protein ID WP_005916679.1
Coordinates 5049411..5049827 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AMD14_RS22060 Protein ID WP_005916676.1
Coordinates 5049160..5049414 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD14_RS22035 5045282..5045501 + 220 Protein_4212 RNA 2'-phosphotransferase -
AMD14_RS22040 5045658..5046923 + 1266 WP_015463799.1 cardiolipin synthase B -
AMD14_RS22045 5046949..5047476 - 528 WP_005916668.1 hypothetical protein -
AMD14_RS22050 5047715..5047921 + 207 WP_003489327.1 hypothetical protein -
AMD14_RS22055 5047908..5049014 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AMD14_RS22060 5049160..5049414 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AMD14_RS22065 5049411..5049827 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AMD14_RS24805 5049949..5050152 - 204 WP_131830033.1 hypothetical protein -
AMD14_RS24810 5050280..5050492 - 213 WP_015472901.1 hypothetical protein -
AMD14_RS22070 5050749..5052368 + 1620 WP_015463800.1 hypothetical protein -
AMD14_RS22075 5052472..5052870 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AMD14_RS22080 5053186..5053617 + 432 WP_005922907.1 hypothetical protein -
AMD14_RS24385 5053646..5053972 - 327 Protein_4224 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T48036 WP_005916679.1 NZ_CP008998:5049411-5049827 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T48036 NZ_CP008998:5049411-5049827 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT48036 WP_005916676.1 NZ_CP008998:5049160-5049414 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT48036 NZ_CP008998:5049160-5049414 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References