Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 18225..18814 Replicon plasmid pXAC33
Accession NZ_CP008996
Organism Xanthomonas citri pv. citri strain MN12

Toxin (Protein)


Gene name pemK Uniprot ID M4U123
Locus tag AMD14_RS00110 Protein ID WP_015463824.1
Coordinates 18225..18557 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID M4UHU6
Locus tag AMD14_RS00115 Protein ID WP_011052949.1
Coordinates 18557..18814 (-) Length 86 a.a.

Genomic Context

AMD14_RS00120AMD14_RS22410AMD14_RS24440AMD14_RS00100AMD14_RS00105AMD14_RS24445AMD14_RS00110AMD14_RS00115AMD14_RS00125AMD14_RS22415AMD14_RS00130AMD14_RS24450
Location: 19020..19622 (603 bp)
Type: Others
Protein ID: WP_011052950.1
Location: 19606..19910 (305 bp)
Type: Others
Protein ID: Protein_28
Location: 16705..16926 (222 bp)
Type: Others
Protein ID: WP_011052944.1
Location: 17216..17752 (537 bp)
Type: Others
Protein ID: WP_015463823.1
Location: 17742..17954 (213 bp)
Type: Others
Protein ID: WP_011052947.1
Location: 17951..18202 (252 bp)
Type: Others
Protein ID: WP_125459571.1
Location: 18225..18557 (333 bp)
Type: Toxin
Protein ID: WP_015463824.1
Location: 18557..18814 (258 bp)
Type: Antitoxin
Protein ID: WP_011052949.1
Location: 20077..20283 (207 bp)
Type: Others
Protein ID: Protein_29
Location: 20328..20897 (570 bp)
Type: Others
Protein ID: Protein_30
Location: 20916..22130 (1215 bp)
Type: Others
Protein ID: WP_011050083.1
Location: 22204..22386 (183 bp)
Type: Others
Protein ID: Protein_32
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AMD14_RS2444016705..16926-222WP_011052944.1hypothetical protein-
AMD14_RS0010017216..17752-537WP_015463823.1plasmid pRiA4b ORF-3 family protein-
AMD14_RS0010517742..17954-213WP_011052947.1hypothetical protein-
AMD14_RS2444517951..18202-252WP_125459571.1hypothetical protein-
AMD14_RS0011018225..18557-333WP_015463824.1type II toxin-antitoxin system PemK/MazF family toxinToxin
AMD14_RS0011518557..18814-258WP_011052949.1antitoxinAntitoxin
AMD14_RS0012019020..19622+603WP_011052950.1recombinase family protein-
AMD14_RS2241019606..19910+305Protein_28Tn3 family transposase-
AMD14_RS0012520077..20283-207Protein_29Tn3 family transposase-
AMD14_RS2241520328..20897-570Protein_30UPF0149 family protein-
AMD14_RS0013020916..22130-1215WP_011050083.1IS4-like element ISXac1 family transposase-
AMD14_RS2445022204..22386-183Protein_32UPF0149 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..3370333703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11707.46 Da        Isoelectric Point: 9.1975

>T48029 WP_015463824.1 NZ_CP008996:c18557-18225 [Xanthomonas citri pv. citri]
MDRGDVYLVSLDPTSGHEQQGTRPVLIVSPSAFNRLTKTPVVLPITSGGNFARTAGFTVSLMGAGTNTTGVVRCDQPRAL
DLASRRARKLETVPSPIMDEVLAKLSAILE

Download         Length: 333 bp

>T48029 NZ_CP008996:c18557-18225 [Xanthomonas citri pv. citri]
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9242.70 Da        Isoelectric Point: 4.7164

>AT48029 WP_011052949.1 NZ_CP008996:c18814-18557 [Xanthomonas citri pv. citri]
MHTTNLRKVGGSIMLAVPPAILDMLRLRAGATVGLAVDHGRLVIEPTLRPYYSLDELLAQCDASAELSTEDREWLDAKPV
GSELL

Download         Length: 258 bp

>AT48029 NZ_CP008996:c18814-18557 [Xanthomonas citri pv. citri]
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBM4U123

Antitoxin

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Source
ID
Structure
AlphaFold DBM4UHU6

References