Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5099885..5100552 Replicon chromosome
Accession NZ_CP008995
Organism Xanthomonas citri pv. citri strain NT17

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AMD13_RS22210 Protein ID WP_005916679.1
Coordinates 5100136..5100552 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AMD13_RS22205 Protein ID WP_005916676.1
Coordinates 5099885..5100139 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD13_RS22180 5096007..5096226 + 220 Protein_4256 RNA 2'-phosphotransferase -
AMD13_RS22185 5096383..5097648 + 1266 WP_015463799.1 cardiolipin synthase B -
AMD13_RS22190 5097674..5098201 - 528 WP_005916668.1 hypothetical protein -
AMD13_RS22195 5098440..5098646 + 207 WP_003489327.1 hypothetical protein -
AMD13_RS22200 5098633..5099739 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AMD13_RS22205 5099885..5100139 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AMD13_RS22210 5100136..5100552 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AMD13_RS25085 5100674..5100877 - 204 WP_125460668.1 hypothetical protein -
AMD13_RS25090 5101005..5101217 - 213 WP_015472901.1 hypothetical protein -
AMD13_RS22215 5101474..5103093 + 1620 WP_015463800.1 hypothetical protein -
AMD13_RS22220 5103197..5103595 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AMD13_RS22225 5103911..5104342 + 432 WP_005922907.1 hypothetical protein -
AMD13_RS24575 5104371..5104697 - 327 Protein_4268 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T48028 WP_005916679.1 NZ_CP008995:5100136-5100552 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T48028 NZ_CP008995:5100136-5100552 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT48028 WP_005916676.1 NZ_CP008995:5099885-5100139 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT48028 NZ_CP008995:5099885-5100139 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References