Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5048085..5048752 Replicon chromosome
Accession NZ_CP008989
Organism Xanthomonas citri pv. citri strain UI7

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AMD18_RS22050 Protein ID WP_005916679.1
Coordinates 5048336..5048752 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AMD18_RS22045 Protein ID WP_005916676.1
Coordinates 5048085..5048339 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD18_RS22020 5044207..5044426 + 220 Protein_4221 RNA 2'-phosphotransferase -
AMD18_RS22025 5044583..5045848 + 1266 WP_015463799.1 cardiolipin synthase B -
AMD18_RS22030 5045874..5046401 - 528 WP_005916668.1 hypothetical protein -
AMD18_RS22035 5046640..5046846 + 207 WP_003489327.1 hypothetical protein -
AMD18_RS22040 5046833..5047939 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AMD18_RS22045 5048085..5048339 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AMD18_RS22050 5048336..5048752 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AMD18_RS24845 5048874..5049077 - 204 WP_131830033.1 hypothetical protein -
AMD18_RS24850 5049205..5049417 - 213 WP_015472901.1 hypothetical protein -
AMD18_RS22055 5049674..5051293 + 1620 WP_015463800.1 hypothetical protein -
AMD18_RS22060 5051397..5051795 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AMD18_RS22065 5052111..5052542 + 432 WP_005922907.1 hypothetical protein -
AMD18_RS24400 5052571..5052897 - 327 Protein_4233 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T48012 WP_005916679.1 NZ_CP008989:5048336-5048752 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T48012 NZ_CP008989:5048336-5048752 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT48012 WP_005916676.1 NZ_CP008989:5048085-5048339 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT48012 NZ_CP008989:5048085-5048339 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References