Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 31393..31934 Replicon plasmid pXAC64
Accession NZ_CP008988
Organism Xanthomonas citri pv. citri strain UI7

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AMD18_RS00310 Protein ID WP_015462614.1
Coordinates 31393..31719 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H8FMA7
Locus tag AMD18_RS00315 Protein ID WP_003491150.1
Coordinates 31716..31934 (-) Length 73 a.a.

Genomic Context

AMD18_RS00300AMD18_RS00305AMD18_RS00310AMD18_RS00315AMD18_RS00320AMD18_RS00325AMD18_RS00330AMD18_RS00335AMD18_RS00340
Location: 26776..28350 (1575 bp)
Type: Others
Protein ID: WP_011052977.1
Location: 28364..31339 (2976 bp)
Type: Others
Protein ID: WP_011052978.1
Location: 31393..31719 (327 bp)
Type: Toxin
Protein ID: WP_015462614.1
Location: 31716..31934 (219 bp)
Type: Antitoxin
Protein ID: WP_003491150.1
Location: 32071..32457 (387 bp)
Type: Others
Protein ID: WP_003491149.1
Location: 32534..32953 (420 bp)
Type: Others
Protein ID: WP_011052981.1
Location: 33079..33957 (879 bp)
Type: Others
Protein ID: WP_011052982.1
Location: 33968..34990 (1023 bp)
Type: Others
Protein ID: WP_011052983.1
Location: 35001..36221 (1221 bp)
Type: Others
Protein ID: WP_011052984.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AMD18_RS0030026776..28350+1575WP_011052977.1type IV secretion system DNA-binding domain-containing protein-
AMD18_RS0030528364..31339+2976WP_011052978.1conjugative relaxase-
AMD18_RS0031031393..31719-327WP_015462614.1type II toxin-antitoxin system PemK/MazF family toxinToxin
AMD18_RS0031531716..31934-219WP_003491150.1antitoxin MazE family proteinAntitoxin
AMD18_RS0032032071..32457-387WP_003491149.1hypothetical protein-
AMD18_RS0032532534..32953-420WP_011052981.1hypothetical protein-
AMD18_RS0033033079..33957-879WP_011052982.1transglycosylase SLT domain-containing protein-
AMD18_RS0033533968..34990-1023WP_011052983.1P-type DNA transfer ATPase VirB11-
AMD18_RS0034035001..36221-1221WP_011052984.1TrbI/VirB10 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..6492064920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(5-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11676.70 Da        Isoelectric Point: 9.2550

>T48006 WP_015462614.1 NZ_CP008988:c31719-31393 [Xanthomonas citri pv. citri]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T48006 NZ_CP008988:c31719-31393 [Xanthomonas citri pv. citri]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCAAGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGTATTACCG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8418.54 Da        Isoelectric Point: 5.6599

>AT48006 WP_003491150.1 NZ_CP008988:c31934-31716 [Xanthomonas citri pv. citri]
MAHVNSRVQKHRDALRMAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 219 bp

>AT48006 NZ_CP008988:c31934-31716 [Xanthomonas citri pv. citri]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGCGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGCGGATA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBH8FMA7

References