47980

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1254787..1255265 Replicon chromosome
Accession NZ_CP008957
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag EDL933_RS06130 Protein ID WP_001303876.1
Coordinates 1254787..1255074 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag EDL933_RS06135 Protein ID WP_000536233.1
Coordinates 1255074..1255265 (-) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDL933_RS06095 1249936..1252407 - 2472 WP_000034474.1 exonuclease -
EDL933_RS06100 1252501..1252692 - 192 WP_001098307.1 DUF1482 family protein -
EDL933_RS32085 1252689..1252877 - 189 WP_000413705.1 cell division inhibition protein DicB -
EDL933_RS06115 1253451..1253636 + 186 WP_001133046.1 hypothetical protein -
EDL933_RS06120 1253823..1254212 - 390 WP_000394511.1 hypothetical protein -
EDL933_RS06125 1254354..1254509 - 156 WP_000379575.1 DUF1391 family protein -
EDL933_RS06130 1254787..1255074 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EDL933_RS06135 1255074..1255265 - 192 WP_000536233.1 hypothetical protein Antitoxin
EDL933_RS06140 1255293..1255694 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
EDL933_RS06145 1255803..1256075 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
EDL933_RS06150 1256059..1256484 + 426 WP_000693855.1 Rha family transcriptional regulator -
EDL933_RS32100 1256691..1257146 - 456 WP_000273724.1 hypothetical protein -
EDL933_RS06160 1257225..1258316 + 1092 WP_001205823.1 hypothetical protein -
EDL933_RS06165 1258323..1259069 + 747 WP_000788751.1 ATP-binding protein -
EDL933_RS06170 1259091..1259861 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T47980 WP_001303876.1 NZ_CP008957:c1255074-1254787 [Escherichia coli O157:H7 str. EDL933]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T47980 NZ_CP008957:c1255074-1254787 [Escherichia coli O157:H7 str. EDL933]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT47980 WP_000536233.1 NZ_CP008957:c1255265-1255074 [Escherichia coli O157:H7 str. EDL933]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT47980 NZ_CP008957:c1255265-1255074 [Escherichia coli O157:H7 str. EDL933]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References