47979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1000838..1001543 Replicon chromosome
Accession NZ_CP008957
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag EDL933_RS04785 Protein ID WP_000539519.1
Coordinates 1001157..1001543 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EDL933_RS04780 Protein ID WP_001280945.1
Coordinates 1000838..1001167 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDL933_RS04765 995995..996906 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
EDL933_RS04770 997084..999432 + 2349 WP_000950320.1 EAL domain-containing protein -
EDL933_RS04775 999440..1000768 + 1329 WP_000086905.1 GGDEF domain-containing protein -
EDL933_RS04780 1000838..1001167 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
EDL933_RS04785 1001157..1001543 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EDL933_RS04790 1001769..1003094 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
EDL933_RS04795 1003307..1003690 + 384 WP_000497137.1 biofilm formation regulator BssR -
EDL933_RS04800 1003801..1004916 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
EDL933_RS04805 1004913..1005539 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T47979 WP_000539519.1 NZ_CP008957:c1001543-1001157 [Escherichia coli O157:H7 str. EDL933]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T47979 NZ_CP008957:c1001543-1001157 [Escherichia coli O157:H7 str. EDL933]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT47979 WP_001280945.1 NZ_CP008957:c1001167-1000838 [Escherichia coli O157:H7 str. EDL933]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT47979 NZ_CP008957:c1001167-1000838 [Escherichia coli O157:H7 str. EDL933]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References