Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3522342..3523035 Replicon chromosome
Accession NZ_CP008956
Organism Herbaspirillum rubrisubalbicans Os34

Toxin (Protein)


Gene name tad Uniprot ID A0A6M3ZTU3
Locus tag C798_RS15910 Protein ID WP_017450287.1
Coordinates 3522342..3522719 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0U3CND7
Locus tag C798_RS15915 Protein ID WP_017450286.1
Coordinates 3522700..3523035 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C798_RS15885 3518502..3519170 + 669 WP_017450292.1 GntR family transcriptional regulator -
C798_RS15890 3519195..3520094 - 900 WP_017450291.1 pseudouridine synthase -
C798_RS15895 3520091..3521428 - 1338 WP_017450290.1 type II toxin-antitoxin system HipA family toxin -
C798_RS15900 3521425..3521727 - 303 WP_017450289.1 helix-turn-helix domain-containing protein -
C798_RS15905 3521947..3522135 - 189 WP_017450288.1 YjfB family protein -
C798_RS15910 3522342..3522719 + 378 WP_017450287.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C798_RS15915 3522700..3523035 + 336 WP_017450286.1 helix-turn-helix domain-containing protein Antitoxin
C798_RS15920 3523109..3523297 - 189 WP_017450285.1 hypothetical protein -
C798_RS15925 3523486..3524328 - 843 WP_017450284.1 anti-sigma factor -
C798_RS15930 3524325..3524882 - 558 WP_017450283.1 RNA polymerase sigma factor -
C798_RS15935 3524900..3525271 - 372 WP_017450282.1 hypothetical protein -
C798_RS15940 3525370..3525810 - 441 WP_017450281.1 group 1 truncated hemoglobin -
C798_RS15945 3525835..3526851 - 1017 WP_017450280.1 DUF3034 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-96)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14055.25 Da        Isoelectric Point: 9.7276

>T47973 WP_017450287.1 NZ_CP008956:3522342-3522719 [Herbaspirillum rubrisubalbicans Os34]
MFTNEKPLEWIASSYKDLMALPAEVRQRFGFALSLAQMGERDDTAKVLKGFGGAGVLEVVEYQMGNAYRAVYTVKFEEAV
FVLHCFQKKSKSGIATPHTEMDIVRTRLNVAAARAEELKHAKKNR

Download         Length: 378 bp

>T47973 NZ_CP008956:3522342-3522719 [Herbaspirillum rubrisubalbicans Os34]
ATGTTTACCAATGAGAAACCGCTCGAATGGATTGCGAGCAGCTACAAGGATCTGATGGCGCTGCCTGCGGAGGTTCGTCA
GCGTTTCGGCTTTGCCCTGTCGCTTGCCCAGATGGGAGAGCGCGACGATACGGCCAAGGTCTTGAAAGGTTTCGGCGGTG
CCGGGGTATTGGAAGTTGTCGAATACCAAATGGGCAATGCCTACCGCGCGGTCTACACGGTGAAATTCGAAGAAGCGGTG
TTCGTGCTGCATTGCTTTCAGAAAAAGAGCAAAAGCGGCATCGCTACTCCACACACGGAGATGGACATCGTTCGGACACG
TCTCAACGTGGCCGCAGCAAGAGCCGAGGAATTGAAACATGCAAAAAAGAATCGTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12286.51 Da        Isoelectric Point: 10.4695

>AT47973 WP_017450286.1 NZ_CP008956:3522700-3523035 [Herbaspirillum rubrisubalbicans Os34]
MQKRIVEETEVLRSTSNVFADLGLPQADKLRIKTGLVIEIRKAMRALGLTQQAAAQRMGIPQPKVSGMMRGDFSNLSERK
LMDCLNRLGYDIDIRVCPATATVGQLKLTVV

Download         Length: 336 bp

>AT47973 NZ_CP008956:3522700-3523035 [Herbaspirillum rubrisubalbicans Os34]
ATGCAAAAAAGAATCGTTGAAGAAACCGAAGTCCTGCGCAGCACCAGCAACGTCTTCGCGGACCTGGGATTGCCACAGGC
CGACAAGCTGCGCATCAAGACCGGGCTGGTGATCGAAATCCGCAAGGCCATGCGCGCCCTTGGACTTACCCAGCAAGCGG
CGGCGCAGCGCATGGGGATTCCACAACCGAAGGTGTCGGGCATGATGCGCGGTGACTTCAGCAATCTTTCCGAGCGCAAG
TTAATGGATTGTCTGAATCGACTGGGTTATGACATCGATATCCGGGTGTGCCCCGCTACCGCTACGGTAGGACAATTGAA
GCTCACGGTCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M3ZTU3

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3CND7

References