Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4635665..4636299 Replicon chromosome
Accession NZ_CP008943
Organism Yersinia pseudotuberculosis strain ATCC 6904

Toxin (Protein)


Gene name hicA Uniprot ID A0A0T9QKF4
Locus tag DJ40_RS21020 Protein ID WP_025383392.1
Coordinates 4635665..4635841 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A380Q6Q6
Locus tag DJ40_RS21025 Protein ID WP_038401436.1
Coordinates 4635892..4636299 (+) Length 136 a.a.

Genomic Context

DJ40_RS20975DJ40_RS20980DJ40_RS20985DJ40_RS20990DJ40_RS20995DJ40_RS21000DJ40_RS21005DJ40_RS23100DJ40_RS21020DJ40_RS21025DJ40_RS21030DJ40_RS21040DJ40_RS21045DJ40_RS21050DJ40_RS21035
Location: 4630698..4631453 (756 bp)
Type: Others
Protein ID: WP_038401885.1
Location: 4631450..4632187 (738 bp)
Type: Others
Protein ID: WP_038401426.1
Location: 4632272..4632610 (339 bp)
Type: Others
Protein ID: WP_038401427.1
Location: 4632600..4632995 (396 bp)
Type: Others
Protein ID: WP_038401429.1
Location: 4633231..4633698 (468 bp)
Type: Others
Protein ID: WP_038401887.1
Location: 4633909..4634091 (183 bp)
Type: Others
Protein ID: WP_038401431.1
Location: 4634328..4634696 (369 bp)
Type: Others
Protein ID: WP_038401432.1
Location: 4634727..4635332 (606 bp)
Type: Others
Protein ID: WP_071840332.1
Location: 4635665..4635841 (177 bp)
Type: Toxin
Protein ID: WP_025383392.1
Location: 4635892..4636299 (408 bp)
Type: Antitoxin
Protein ID: WP_038401436.1
Location: 4636356..4637960 (1605 bp)
Type: Others
Protein ID: WP_038401438.1
Location: 4638604..4639245 (642 bp)
Type: Others
Protein ID: WP_200876958.1
Location: 4639249..4639470 (222 bp)
Type: Others
Protein ID: WP_038401443.1
Location: 4639463..4641244 (1782 bp)
Type: Others
Protein ID: WP_038401445.1
Location: 4638058..4638540 (483 bp)
Type: Others
Protein ID: WP_144243032.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DJ40_RS209754630698..4631453+756WP_038401885.1serine/threonine protein kinase-
DJ40_RS209804631450..4632187+738WP_038401426.1protein phosphatase 2C domain-containing protein-
DJ40_RS209854632272..4632610+339WP_038401427.1phage holin, lambda family-
DJ40_RS209904632600..4632995+396WP_038401429.1M15 family metallopeptidase-
DJ40_RS209954633231..4633698+468WP_038401887.1lysis protein-
DJ40_RS210004633909..4634091+183WP_038401431.1hypothetical protein-
DJ40_RS210054634328..4634696+369WP_038401432.1hypothetical protein-
DJ40_RS231004634727..4635332+606WP_071840332.1terminase small subunit-
DJ40_RS210204635665..4635841+177WP_025383392.1type II toxin-antitoxin system HicA family toxinToxin
DJ40_RS210254635892..4636299+408WP_038401436.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
DJ40_RS210304636356..4637960+1605WP_038401438.1bacteriophage TerL protein-
DJ40_RS210354638058..4638540-483WP_144243032.1DUF1073 domain-containing protein-
DJ40_RS210404638604..4639245+642WP_200876958.1hypothetical protein-
DJ40_RS210454639249..4639470+222WP_038401443.1hypothetical protein-
DJ40_RS210504639463..4641244+1782WP_038401445.1phage tail protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4623642..464248418842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(79-131)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6649.82 Da        Isoelectric Point: 11.4350

>T47967 WP_025383392.1 NZ_CP008943:4635665-4635841 [Yersinia pseudotuberculosis]
VKQREFQRWLAGQGAEFSNGTNHLKIFLNGKQTIMPRHPGKEIPEPLRKAILKQLGLK

Download         Length: 177 bp

>T47967 NZ_CP008943:4635665-4635841 [Yersinia pseudotuberculosis]
GTGAAACAACGCGAGTTCCAGCGTTGGCTAGCGGGGCAAGGAGCTGAATTTTCGAATGGCACTAATCACTTGAAGATTTT
CTTAAACGGCAAGCAAACGATAATGCCAAGACATCCAGGGAAAGAAATACCGGAGCCTCTGAGAAAAGCGATTCTTAAGC
AACTTGGACTTAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14784.90 Da        Isoelectric Point: 4.5034

>AT47967 WP_038401436.1 NZ_CP008943:4635892-4636299 [Yersinia pseudotuberculosis]
MRYPIKFEHDETGWCISFPDIPEALTGGATKEEALSLAQDALVTSFDFYFEDQRPVPMPSTDGDEFIEVPASVAAKVLLL
NAMLATGTTPAELARRLGTRPQDVNRIVNLGHTTKIDTIEAALKALGKRLEINVL

Download         Length: 408 bp

>AT47967 NZ_CP008943:4635892-4636299 [Yersinia pseudotuberculosis]
ATGCGATATCCAATAAAATTTGAGCATGACGAAACCGGGTGGTGTATATCGTTCCCGGATATACCCGAGGCATTAACTGG
CGGGGCTACAAAGGAAGAAGCGCTATCATTGGCGCAAGACGCCCTTGTAACGTCGTTTGATTTCTATTTTGAAGACCAGC
GCCCGGTACCCATGCCGAGCACAGACGGTGATGAGTTTATCGAGGTGCCTGCAAGCGTGGCCGCCAAAGTGCTATTGCTT
AACGCTATGCTGGCTACAGGAACAACACCGGCAGAGCTTGCCCGCCGCCTAGGTACACGACCGCAAGACGTTAACCGCAT
TGTTAATCTTGGGCACACGACAAAAATCGACACGATAGAAGCGGCGCTTAAGGCGCTAGGTAAGCGTTTAGAAATAAACG
TTCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0T9QKF4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A380Q6Q6

References