Detailed information of TA system TA047966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4089490..4090085
• Replicon: chromosome
• Accession: NZ_CP008943
• Organism: Yersinia pseudotuberculosis strain ATCC 6904

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A0T9RS91
• Locus tag: DJ40_RS18555
• Protein ID: WP_025383660.1
• Coordinates: 4089711..4090085 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A380Q623
• Locus tag: DJ40_RS18550
• Protein ID: WP_038401206.1
• Coordinates: 4089490..4089714 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DJ40_RS18520	4084863..4085036	+	174	WP_162472804.1	lytic transglycosylase	-
DJ40_RS18525	4085029..4087047	+	2019	WP_038401195.1	lytic transglycosylase domain-containing protein	-
DJ40_RS18530	4087047..4087673	+	627	WP_038401197.1	hypothetical protein	-
DJ40_RS18535	4087670..4087975	+	306	WP_038401199.1	hypothetical protein	-
DJ40_RS18540	4087978..4089039	+	1062	WP_038401201.1	hypothetical protein	-
DJ40_RS18545	4089040..4089378	+	339	WP_038401203.1	hypothetical protein	-
DJ40_RS18550	4089490..4089714	+	225	WP_038401206.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DJ40_RS18555	4089711..4090085	+	375	WP_025383660.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
DJ40_RS18560	4090148..4090906	+	759	WP_038401208.1	hypothetical protein	-
DJ40_RS18565	4090903..4091256	+	354	WP_038401210.1	bacteriophage protein	-
DJ40_RS18570	4091257..4092444	+	1188	WP_038401211.1	baseplate J/gp47 family protein	-
DJ40_RS18575	4092444..4093118	+	675	WP_038401213.1	DUF2612 domain-containing protein	-
DJ40_RS21935	4093111..4094109	+	999	WP_049862796.1	phage tail protein	-
DJ40_RS18590	4094111..4094578	+	468	WP_042592787.1	tail fiber assembly protein	-
DJ40_RS18595	4094750..4095028	-	279	WP_012303833.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4056516..4106185	49669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-54)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13360.20 Da
• Isoelectric Point: 4.6194

>T47966 WP_025383660.1 NZ_CP008943:4089711-4090085 [Yersinia pseudotuberculosis]
MIFFLSVEQVIAIHDSQLESYGGLAGYRDIGLVEGMVARVENLHAYQGESDLFVLAASLLLSIARGHGFNDANKRTSVAS
AMVFLDMNGAPIIPTEGFADFVVEAAQGIHDVHAVAQELKRLTN

Nucleotide

• Length: 375 bp

>T47966 NZ_CP008943:4089711-4090085 [Yersinia pseudotuberculosis]
ATGATTTTTTTCTTATCTGTTGAGCAGGTCATAGCCATCCACGACAGTCAGTTAGAGTCTTATGGTGGGCTGGCAGGATA
CAGAGATATTGGTCTTGTTGAAGGAATGGTGGCCCGCGTTGAAAACCTTCATGCATACCAGGGTGAAAGTGATTTGTTTG
TGCTGGCCGCGTCGCTGTTGCTTTCAATAGCTCGAGGGCATGGCTTCAATGATGCAAATAAAAGAACTTCTGTTGCATCA
GCAATGGTATTTCTGGATATGAATGGTGCACCCATAATTCCGACAGAGGGTTTCGCTGACTTTGTGGTAGAAGCGGCGCA
GGGAATTCATGATGTGCATGCTGTAGCGCAAGAGCTGAAGAGGCTCACAAATTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8215.49 Da
• Isoelectric Point: 10.0941

>AT47966 WP_038401206.1 NZ_CP008943:4089490-4089714 [Yersinia pseudotuberculosis]
MITLTFSDARQKFSSVLDTAVNQPVTITRRSAPDMVVITAEQFAELQQAKFDASLARVMGKPKNQALFKELADK

Nucleotide

• Length: 225 bp

>AT47966 NZ_CP008943:4089490-4089714 [Yersinia pseudotuberculosis]
ATGATCACCCTGACCTTTTCCGATGCTCGTCAGAAATTTTCCAGCGTACTAGATACCGCCGTCAATCAGCCCGTGACGAT
TACCCGCCGTTCAGCTCCTGATATGGTGGTCATCACTGCTGAGCAGTTTGCAGAGTTACAGCAGGCTAAATTTGATGCGT
CTCTTGCTCGGGTGATGGGCAAGCCAAAGAATCAGGCCTTGTTCAAGGAACTTGCAGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0T9RS91

Antitoxin

• AlphaFold DB: A0A380Q623