Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3771424..3772096 Replicon chromosome
Accession NZ_CP008943
Organism Yersinia pseudotuberculosis strain ATCC 6904

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag DJ40_RS16915 Protein ID WP_002215144.1
Coordinates 3771671..3772096 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag DJ40_RS16910 Protein ID WP_002209939.1
Coordinates 3771424..3771690 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJ40_RS16890 3767265..3768368 + 1104 WP_011192960.1 hypothetical protein -
DJ40_RS16895 3768569..3769270 + 702 WP_011192959.1 hemolysin III family protein -
DJ40_RS16900 3769545..3770042 + 498 WP_002209941.1 DUF2165 family protein -
DJ40_RS16905 3770115..3771107 - 993 WP_011192958.1 tRNA-modifying protein YgfZ -
DJ40_RS16910 3771424..3771690 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
DJ40_RS16915 3771671..3772096 + 426 WP_002215144.1 protein YgfX Toxin
DJ40_RS16920 3772096..3772794 + 699 WP_002209937.1 two-component system response regulator CreB -
DJ40_RS16925 3772805..3774223 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
DJ40_RS16930 3774344..3775801 + 1458 WP_032466588.1 cell envelope integrity protein CreD -
DJ40_RS16935 3775886..3776404 - 519 WP_011192956.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T47964 WP_002215144.1 NZ_CP008943:3771671-3772096 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T47964 NZ_CP008943:3771671-3772096 [Yersinia pseudotuberculosis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT47964 WP_002209939.1 NZ_CP008943:3771424-3771690 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT47964 NZ_CP008943:3771424-3771690 [Yersinia pseudotuberculosis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References