Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1488163..1488783 Replicon chromosome
Accession NZ_CP008943
Organism Yersinia pseudotuberculosis strain ATCC 6904

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag DJ40_RS06875 Protein ID WP_002208622.1
Coordinates 1488580..1488783 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9PQI8
Locus tag DJ40_RS06870 Protein ID WP_025382853.1
Coordinates 1488163..1488531 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJ40_RS06855 1486358..1486618 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
DJ40_RS06860 1486634..1486777 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
DJ40_RS06865 1487651..1488004 + 354 WP_002208619.1 hypothetical protein -
DJ40_RS06870 1488163..1488531 + 369 WP_025382853.1 Hha toxicity modulator TomB Antitoxin
DJ40_RS06875 1488580..1488783 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
DJ40_RS06880 1489689..1490078 + 390 WP_024063215.1 MGMT family protein -
DJ40_RS06885 1490214..1490735 - 522 WP_011191872.1 YbaY family lipoprotein -
DJ40_RS06890 1490992..1491852 + 861 WP_002208625.1 acyl-CoA thioesterase II -
DJ40_RS06895 1492113..1493402 - 1290 WP_002228344.1 ammonium transporter AmtB -
DJ40_RS06900 1493442..1493780 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T47962 WP_002208622.1 NZ_CP008943:1488580-1488783 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T47962 NZ_CP008943:1488580-1488783 [Yersinia pseudotuberculosis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.98 Da        Isoelectric Point: 4.5221

>AT47962 WP_025382853.1 NZ_CP008943:1488163-1488531 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSELSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT47962 NZ_CP008943:1488163-1488531 [Yersinia pseudotuberculosis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCGAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9PQI8

References