47931

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2269149..2269665 Replicon chromosome
Accession NZ_CP008929
Organism Klebsiella pneumoniae strain PMK1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag PMK1_RS11120 Protein ID WP_004178374.1
Coordinates 2269381..2269665 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PMK1_RS11115 Protein ID WP_002886901.1
Coordinates 2269149..2269391 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMK1_RS11100 2265177..2265917 + 741 WP_002886899.1 KDGP aldolase family protein -
PMK1_RS11105 2265984..2267138 + 1155 WP_004178372.1 lactonase family protein -
PMK1_RS11110 2267161..2269071 + 1911 WP_004178373.1 BglG family transcription antiterminator -
PMK1_RS11115 2269149..2269391 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PMK1_RS11120 2269381..2269665 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMK1_RS11125 2269669..2270133 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PMK1_RS11130 2270374..2272512 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PMK1_RS11140 2272869..2273612 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PMK1_RS32850 2273615..2273788 - 174 WP_032408826.1 hypothetical protein -
PMK1_RS11150 2273873..2274181 + 309 WP_022631369.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T47931 WP_004178374.1 NZ_CP008929:2269381-2269665 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T47931 NZ_CP008929:2269381-2269665 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT47931 WP_002886901.1 NZ_CP008929:2269149-2269391 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT47931 NZ_CP008929:2269149-2269391 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References