Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884627..885284 Replicon chromosome
Accession NZ_CP008929
Organism Klebsiella pneumoniae strain PMK1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag PMK1_RS04235 Protein ID WP_002916310.1
Coordinates 884627..885037 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PMK1_RS04240 Protein ID WP_002916312.1
Coordinates 885018..885284 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMK1_RS04215 880627..882360 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
PMK1_RS04220 882366..883079 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PMK1_RS04225 883102..883998 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PMK1_RS04230 884099..884620 + 522 WP_004144730.1 flavodoxin FldB -
PMK1_RS04235 884627..885037 - 411 WP_002916310.1 protein YgfX Toxin
PMK1_RS04240 885018..885284 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PMK1_RS04245 885530..886513 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
PMK1_RS04250 886664..887323 - 660 WP_002916317.1 hemolysin III family protein -
PMK1_RS04255 887487..887798 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PMK1_RS04260 887848..888576 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
PMK1_RS04265 888695..890128 + 1434 WP_020324925.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T47926 WP_002916310.1 NZ_CP008929:c885037-884627 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T47926 NZ_CP008929:c885037-884627 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT47926 WP_002916312.1 NZ_CP008929:c885284-885018 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT47926 NZ_CP008929:c885284-885018 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References