Detailed information of TA system TA047925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2084263..2084869
• Replicon: chromosome
• Accession: NZ_CP008921
• Organism: Streptococcus suis 6407

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075SGI8
• Locus tag: ID09_RS10250
• Protein ID: WP_024381176.1
• Coordinates: 2084263..2084592 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A075SKR5
• Locus tag: ID09_RS10255
• Protein ID: WP_024381177.1
• Coordinates: 2084582..2084869 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ID09_RS10220	2079678..2081408	-	1731	WP_024381172.1	membrane protein	-
ID09_RS10225	2081770..2082678	-	909	WP_074390583.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
ID09_RS10230	2082662..2083192	-	531	WP_024381173.1	DUF1697 domain-containing protein	-
ID09_RS10235	2083206..2083463	-	258	WP_024381174.1	Txe/YoeB family addiction module toxin	-
ID09_RS10240	2083465..2083725	-	261	WP_029693774.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ID09_RS10245	2083801..2084256	-	456	WP_024381175.1	8-oxo-dGTP diphosphatase	-
ID09_RS10250	2084263..2084592	-	330	WP_024381176.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ID09_RS10255	2084582..2084869	-	288	WP_024381177.1	hypothetical protein	Antitoxin
ID09_RS10260	2084967..2085335	-	369	WP_024381178.1	hypothetical protein	-
ID09_RS10265	2085328..2085894	-	567	WP_024381179.1	ribonuclease M5	-
ID09_RS10270	2085878..2086660	-	783	WP_024381180.1	TatD family hydrolase	-
ID09_RS10275	2086767..2086904	-	138	WP_002939016.1	50S ribosomal protein L34	-
ID09_RS10280	2087072..2088067	-	996	WP_024381181.1	protein jag	-
ID09_RS10285	2088087..2088899	-	813	WP_024381182.1	membrane protein insertase YidC	-
ID09_RS10290	2088883..2089242	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12575.52 Da
• Isoelectric Point: 8.3572

>T47925 WP_024381176.1 NZ_CP008921:c2084592-2084263 [Streptococcus suis 6407]
MEFESYSVILAPAVERELAAIYAYFSEQFSEEIAKRRIGMIVQALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T47925 NZ_CP008921:c2084592-2084263 [Streptococcus suis 6407]
ATGGAATTTGAGTCATATTCAGTGATACTTGCTCCAGCAGTGGAGAGGGAATTGGCAGCTATTTACGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCCAAGCTTTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTAACCCGAGGTTACGTTATTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTGGGTCACCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10897.49 Da
• Isoelectric Point: 4.3472

>AT47925 WP_024381177.1 NZ_CP008921:c2084869-2084582 [Streptococcus suis 6407]
MITIKKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GQGISLESVKEKYGI

Nucleotide

• Length: 288 bp

>AT47925 NZ_CP008921:c2084869-2084582 [Streptococcus suis 6407]
TTGATAACTATAAAGAAGGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CTGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGCTTCAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCAAGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Structures

Toxin

• AlphaFold DB: A0A075SGI8

Antitoxin

• AlphaFold DB: A0A075SKR5