Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1970124..1970739 Replicon chromosome
Accession NZ_CP008921
Organism Streptococcus suis 6407

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag ID09_RS09625 Protein ID WP_024389183.1
Coordinates 1970124..1970459 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A075SJ65
Locus tag ID09_RS09630 Protein ID WP_024381089.1
Coordinates 1970452..1970739 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID09_RS09605 1966015..1966200 - 186 WP_009910840.1 hypothetical protein -
ID09_RS09610 1966194..1966967 - 774 WP_024381086.1 nucleoside phosphorylase -
ID09_RS09615 1966982..1967599 - 618 WP_015647409.1 serine O-acetyltransferase -
ID09_RS09620 1967653..1969872 - 2220 WP_024381087.1 polyribonucleotide nucleotidyltransferase -
ID09_RS09625 1970124..1970459 - 336 WP_024389183.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ID09_RS09630 1970452..1970739 - 288 WP_024381089.1 XRE family transcriptional regulator Antitoxin
ID09_RS09635 1971053..1971322 - 270 WP_002938849.1 30S ribosomal protein S15 -
ID09_RS09640 1971577..1972218 - 642 WP_002938850.1 ABC transporter ATP-binding protein -
ID09_RS09645 1972211..1972942 - 732 WP_002938851.1 hypothetical protein -
ID09_RS09655 1973706..1974470 - 765 WP_002938853.1 hypothetical protein -
ID09_RS09660 1974555..1974965 - 411 WP_013730575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12818.86 Da        Isoelectric Point: 9.1835

>T47923 WP_024389183.1 NZ_CP008921:c1970459-1970124 [Streptococcus suis 6407]
MDKYQVNLPLAIYEELADIRSYIREELKSPDAADKKIQELIAGLRSLEIFPERGFNVDERSKKGPLVPGQLTRGLPIKKD
YIAIYNIDEAQKVVNVRYLVASKSDYMRLFK

Download         Length: 336 bp

>T47923 NZ_CP008921:c1970459-1970124 [Streptococcus suis 6407]
TTGGATAAGTACCAAGTAAACCTACCTCTAGCTATATATGAGGAACTAGCTGACATTCGTAGCTACATCAGGGAAGAACT
AAAAAGTCCTGATGCTGCGGACAAAAAAATCCAAGAGCTAATAGCAGGACTTAGAAGCCTTGAAATCTTCCCAGAGCGAG
GTTTTAACGTAGATGAACGCTCTAAAAAAGGACCGCTAGTCCCAGGTCAGCTGACGCGAGGATTACCCATCAAAAAGGAT
TATATAGCTATTTATAACATTGATGAAGCACAAAAGGTCGTAAACGTTCGCTATCTTGTCGCAAGCAAGAGCGACTATAT
GAGATTGTTCAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10686.33 Da        Isoelectric Point: 4.2626

>AT47923 WP_024381089.1 NZ_CP008921:c1970739-1970452 [Streptococcus suis 6407]
MALTAEKKLINFQSEKSLVEEAKEVLASQNMTMTQALNLFLKNIVVTGEIGLKSEEELEKERLFAELQAEVMKNVAEMNA
GNYLSLDEMETKLFG

Download         Length: 288 bp

>AT47923 NZ_CP008921:c1970739-1970452 [Streptococcus suis 6407]
ATGGCCTTAACAGCTGAAAAGAAATTGATTAACTTTCAATCAGAAAAATCACTTGTAGAAGAAGCAAAAGAGGTCTTGGC
AAGTCAAAATATGACCATGACACAAGCCCTCAACCTGTTTCTCAAAAATATTGTAGTAACAGGAGAAATTGGGCTTAAAA
GTGAAGAAGAACTGGAAAAAGAGCGACTATTTGCCGAACTGCAAGCAGAAGTGATGAAAAATGTAGCTGAAATGAATGCG
GGCAACTATCTATCATTGGACGAAATGGAGACCAAGCTCTTTGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A075SJ65

References