Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1392818..1393295 Replicon chromosome
Accession NZ_CP008921
Organism Streptococcus suis 6407

Toxin (Protein)


Gene name relE Uniprot ID A0A075SEK1
Locus tag ID09_RS06755 Protein ID WP_029693849.1
Coordinates 1392818..1393078 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A075SIV9
Locus tag ID09_RS06760 Protein ID WP_024381583.1
Coordinates 1393068..1393295 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID09_RS06735 1388648..1389622 - 975 WP_002937257.1 YvcK family protein -
ID09_RS06740 1389619..1390506 - 888 WP_002937261.1 RNase adapter RapZ -
ID09_RS06745 1390528..1390905 - 378 WP_024381582.1 RidA family protein -
ID09_RS06750 1391095..1392403 - 1309 Protein_1293 MATE family efflux transporter -
ID09_RS06755 1392818..1393078 - 261 WP_029693849.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ID09_RS06760 1393068..1393295 - 228 WP_024381583.1 hypothetical protein Antitoxin
ID09_RS06765 1393567..1394913 - 1347 WP_024381711.1 asparagine--tRNA ligase -
ID09_RS06770 1394928..1396109 - 1182 WP_024381710.1 pyridoxal phosphate-dependent aminotransferase -
ID09_RS06775 1396106..1396603 - 498 WP_002938611.1 DUF5590 domain-containing protein -
ID09_RS06780 1396906..1397355 + 450 WP_024381709.1 MarR family transcriptional regulator -
ID09_RS06785 1397418..1397963 + 546 WP_002941732.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-85)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10017.97 Da        Isoelectric Point: 10.2824

>T47922 WP_029693849.1 NZ_CP008921:c1393078-1392818 [Streptococcus suis 6407]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEI

Download         Length: 261 bp

>T47922 NZ_CP008921:c1393078-1392818 [Streptococcus suis 6407]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8480.54 Da        Isoelectric Point: 4.1589

>AT47922 WP_024381583.1 NZ_CP008921:c1393295-1393068 [Streptococcus suis 6407]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKTLKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT47922 NZ_CP008921:c1393295-1393068 [Streptococcus suis 6407]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGACTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075SEK1

Antitoxin

Source ID Structure
AlphaFold DB A0A075SIV9

References