Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 994271..994757 Replicon chromosome
Accession NZ_CP008921
Organism Streptococcus suis 6407

Toxin (Protein)


Gene name relE Uniprot ID A0A075SGM1
Locus tag ID09_RS04845 Protein ID WP_024381850.1
Coordinates 994271..994528 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A075SQT6
Locus tag ID09_RS04850 Protein ID WP_024381851.1
Coordinates 994518..994757 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID09_RS04825 989902..990972 + 1071 WP_024381847.1 tyrosine recombinase XerS -
ID09_RS04830 991042..992550 - 1509 WP_024390639.1 phosphoglucomutase -
ID09_RS04835 992626..993567 - 942 WP_002935009.1 sensor histidine kinase -
ID09_RS04840 993564..994232 - 669 WP_024381849.1 response regulator transcription factor -
ID09_RS04845 994271..994528 - 258 WP_024381850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ID09_RS04850 994518..994757 - 240 WP_024381851.1 hypothetical protein Antitoxin
ID09_RS04855 994847..996817 - 1971 WP_024381852.1 FtsX-like permease family protein -
ID09_RS04860 996818..997570 - 753 WP_024381853.1 ABC transporter ATP-binding protein -
ID09_RS04865 997579..997968 - 390 WP_024381854.1 NisI/SpaI family lantibiotic immunity lipoprotein -
ID09_RS12165 997981..998121 - 141 WP_032505027.1 hypothetical protein -
ID09_RS04875 998259..999425 - 1167 Protein_918 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9854.56 Da        Isoelectric Point: 10.7134

>T47921 WP_024381850.1 NZ_CP008921:c994528-994271 [Streptococcus suis 6407]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIMTSIKM
RNGSI

Download         Length: 258 bp

>T47921 NZ_CP008921:c994528-994271 [Streptococcus suis 6407]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCTCAAAAGCAAATTCGAAAGATGGATAAAACTGCTGCAAGTTTGATTTT
GCGGTATCTTTACAAGCATATTGACGGTTGCGACAACCCCAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGGTACCGTATCGGTAATTACAGGGTCATCGTCAGCATTGAGGATGATAAATTGATTATGACAAGCATAAAAATG
AGAAATGGAAGTATATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8922.12 Da        Isoelectric Point: 3.8812

>AT47921 WP_024381851.1 NZ_CP008921:c994757-994518 [Streptococcus suis 6407]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADRAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT47921 NZ_CP008921:c994757-994518 [Streptococcus suis 6407]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAATTTGAAGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAAACGCTTGAAGCCCTTGAAGATGAATATGATGCCCGTGTGGCAGACAGAGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075SGM1

Antitoxin

Source ID Structure
AlphaFold DB A0A075SQT6

References