Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2117682..2118333 Replicon chromosome
Accession NZ_CP008920
Organism Providencia stuartii strain ATCC 33672

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag DR96_RS09755 Protein ID WP_004927064.1
Coordinates 2117682..2117885 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag DR96_RS09760 Protein ID WP_004927067.1
Coordinates 2117965..2118333 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR96_RS09730 2113560..2113898 + 339 WP_004927053.1 P-II family nitrogen regulator -
DR96_RS09735 2113909..2115192 + 1284 WP_014656764.1 ammonium transporter AmtB -
DR96_RS09740 2115429..2116295 - 867 WP_004927058.1 acyl-CoA thioesterase II -
DR96_RS09745 2116618..2117076 + 459 WP_004927062.1 YbaY family lipoprotein -
DR96_RS09755 2117682..2117885 - 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
DR96_RS09760 2117965..2118333 - 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
DR96_RS09770 2118901..2120238 - 1338 WP_004927077.1 murein transglycosylase D -
DR96_RS09775 2120317..2121072 - 756 WP_040132835.1 hydroxyacylglutathione hydrolase -
DR96_RS09780 2121106..2121831 + 726 WP_040132836.1 methyltransferase domain-containing protein -
DR96_RS09785 2121910..2122380 - 471 WP_014656762.1 ribonuclease HI -
DR96_RS09790 2122435..2123196 + 762 WP_004927092.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T47919 WP_004927064.1 NZ_CP008920:c2117885-2117682 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T47919 NZ_CP008920:c2117885-2117682 [Providencia stuartii]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACCATCGATACACTTGAGCGTGTTATTGAGAAAAATAA
GTATGAGCTTTCTGAAGATGAGTTAGAATTGTTCTATTCAGCTGCTGACCATCGCCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATCCCTGCATCGGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT47919 WP_004927067.1 NZ_CP008920:c2118333-2117965 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT47919 NZ_CP008920:c2118333-2117965 [Providencia stuartii]
ATGGATGAATATTCACCCAAAAATTATGATATATCTGAGTTAAAATACTTGTGTAACAGTTTGAATCGAGAAGCAATGCT
AAGCTTACAGAAAACTAATACACACTGGGTCAATGATTTAAGTTCACCACAAAGTGCTAGACTTAATGAACTCATTGAAC
ATATTGCAGCCTTCGTGTGGCAATTTAAGATAAAATATCCCAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GATGAGACTTATGATTTATTCGGAAGCCCTGTAATAACTCTAAGTGAAATTATTGACTGGCAGAGCATGAATCAAAATCT
AGTTTCCGTACTTGATGATGATTTAAAGTGCCCTGCAAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References