Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 38643..39202 Replicon plasmid unnamed
Accession NZ_CP008919
Organism Providencia stuartii strain ATCC 33672

Toxin (Protein)


Gene name relE Uniprot ID A0A427HAI4
Locus tag DR96_RS00250 Protein ID WP_038601436.1
Coordinates 38924..39202 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8VTV0
Locus tag DR96_RS00245 Protein ID WP_038601434.1
Coordinates 38643..38924 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR96_RS00220 34416..35036 + 621 WP_038601426.1 type-F conjugative transfer system pilin assembly protein TrbC -
DR96_RS00225 35033..36913 + 1881 WP_038601428.1 conjugal transfer protein TraN -
DR96_RS00230 36910..37698 + 789 WP_038601430.1 type-F conjugative transfer system pilin assembly protein TraF -
DR96_RS00235 37709..38011 + 303 WP_038601432.1 hypothetical protein -
DR96_RS00240 38029..38541 + 513 WP_102781171.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
DR96_RS00245 38643..38924 + 282 WP_038601434.1 ribbon-helix-helix domain-containing protein Antitoxin
DR96_RS00250 38924..39202 + 279 WP_038601436.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DR96_RS00255 39476..39874 + 399 WP_038601438.1 hypothetical protein -
DR96_RS00260 40389..41765 + 1377 WP_038601440.1 F-type conjugal transfer protein TraH -
DR96_RS19905 41778..42962 + 1185 WP_052038321.1 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48866 48866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-50)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10787.42 Da        Isoelectric Point: 8.5045

>T47917 WP_038601436.1 NZ_CP008919:38924-39202 [Providencia stuartii]
MELKWTSKALSDLSRVYDFLAFSNTAAAARVVQTLTQAPVSLLVNNPRMGEQLFQFMPHEVRRVVVANYEVRYEIIDSTI
YILRIWHTREDR

Download         Length: 279 bp

>T47917 NZ_CP008919:38924-39202 [Providencia stuartii]
ATGGAGTTAAAGTGGACGAGCAAAGCATTATCGGATCTCTCTCGAGTCTATGATTTTTTGGCCTTCTCAAACACAGCCGC
TGCAGCGCGTGTTGTGCAAACATTGACGCAAGCACCGGTGTCATTGTTGGTAAATAATCCCCGTATGGGTGAACAATTGT
TCCAATTTATGCCACATGAAGTTCGTCGAGTTGTGGTGGCGAATTATGAGGTACGCTATGAAATCATTGACTCGACAATC
TATATTTTGCGGATATGGCACACTCGGGAAGATCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10432.81 Da        Isoelectric Point: 5.6786

>AT47917 WP_038601434.1 NZ_CP008919:38643-38924 [Providencia stuartii]
MKNSSVQNSTKVLTAHVPLAMADKVDEIAARLERSRGWVMKQALSTWIAQEEMRDTLTREALSDVESGRVIDHQFVQDWA
ASLSSDQPLPVPR

Download         Length: 282 bp

>AT47917 NZ_CP008919:38643-38924 [Providencia stuartii]
ATGAAAAACAGTTCGGTACAAAATTCGACAAAAGTGCTAACGGCACATGTGCCCTTAGCGATGGCAGATAAAGTCGATGA
AATCGCGGCTCGCCTCGAACGTTCTCGAGGATGGGTCATGAAACAAGCGCTGTCAACGTGGATAGCTCAGGAGGAGATGC
GGGATACATTGACACGAGAGGCGCTATCAGATGTTGAATCTGGCCGCGTTATTGATCATCAGTTCGTGCAAGATTGGGCC
GCGAGTTTGAGTTCTGACCAGCCATTACCGGTGCCTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427HAI4

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8VTV0

References