Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 816941..818697 Replicon chromosome
Accession NZ_CP008915
Organism Burkholderia thailandensis strain 2003015869

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag DR62_RS20995 Protein ID WP_009900384.1
Coordinates 816941..817846 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag DR62_RS21000 Protein ID WP_009897321.1
Coordinates 817843..818697 (+) Length 285 a.a.

Genomic Context

DR62_RS20970DR62_RS20975DR62_RS20980DR62_RS20985DR62_RS20990DR62_RS20995DR62_RS21000DR62_RS21005DR62_RS21010DR62_RS21015DR62_RS21020DR62_RS20965
Location: 813859..814176 (318 bp)
Type: Others
Protein ID: WP_009897336.1
Location: 814178..814489 (312 bp)
Type: Others
Protein ID: WP_009900387.1
Location: 814524..815591 (1068 bp)
Type: Others
Protein ID: WP_019255252.1
Location: 815588..816358 (771 bp)
Type: Others
Protein ID: WP_009900385.1
Location: 816397..816924 (528 bp)
Type: Others
Protein ID: WP_009897327.1
Location: 816941..817846 (906 bp)
Type: Toxin
Protein ID: WP_009900384.1
Location: 817843..818697 (855 bp)
Type: Antitoxin
Protein ID: WP_009897321.1
Location: 818694..819491 (798 bp)
Type: Others
Protein ID: WP_009897318.1
Location: 819484..821157 (1674 bp)
Type: Others
Protein ID: WP_009900383.1
Location: 821150..821965 (816 bp)
Type: Others
Protein ID: WP_009897315.1
Location: 821987..823477 (1491 bp)
Type: Others
Protein ID: WP_009900381.1
Location: 812336..813424 (1089 bp)
Type: Others
Protein ID: WP_009900389.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DR62_RS20965812336..813424-1089WP_009900389.1porin-
DR62_RS20970813859..814176+318WP_009897336.1non-heme iron oxygenase ferredoxin subunit-
DR62_RS20975814178..814489+312WP_009900387.1hypothetical protein-
DR62_RS20980814524..815591+1068WP_019255252.1aromatic ring-hydroxylating dioxygenase subunit alpha-
DR62_RS20985815588..816358+771WP_009900385.1SDR family oxidoreductase-
DR62_RS20990816397..816924+528WP_009897327.1cupin domain-containing protein-
DR62_RS20995816941..817846+906WP_009900384.1alpha/beta fold hydrolaseToxin
DR62_RS21000817843..818697+855WP_009897321.1IclR family transcriptional regulatorAntitoxin
DR62_RS21005818694..819491+798WP_009897318.1SDR family oxidoreductase-
DR62_RS21010819484..821157+1674WP_009900383.1thiamine pyrophosphate-binding protein-
DR62_RS21015821150..821965+816WP_009897315.1aspartate dehydrogenase-
DR62_RS21020821987..823477+1491WP_009900381.1aldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-bopE / bopA / bicP / bprB / bprD / bprC / tssL-5 / tssK-5 / tssJ-5 / tagD-5 / tagC-5 / tagB-5 / tagAB-5 / tssI-5 / tssH-5/clpV / tssG-5 / tssF-5 / tssE-5 / tssC-5 / tssB-5 / bimA / pmlI/bspI1 / pmlR/bspR1685896..1057600371704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-285)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T47915 WP_009900384.1 NZ_CP008915:816941-817846 [Burkholderia thailandensis]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T47915 NZ_CP008915:816941-817846 [Burkholderia thailandensis]
ATGAGCGCAATCTCCACGACGACTACCGATGCGAGCGCGACGCCGTTCGCCGCGCTGCTCGAACGCTTTGCCGAGCGGCG
CGCGGCCGCGGGCGGCGCGCGTACGATCGGCTATCGCGAAGCGGGCGCGGCGTACGCCGCGCATGCCGGGCGCGATCCCG
TCGTGTTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCGCCCGGCTATGGCGTCTCGTCGCGCGTCGCGGCCGATTCGCCTGTCGCATCCGACTACGCGGCGTC
GCTCGCCGCGTGGCTAGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCG
CGTTCGCGCGGCAAGCGGGCGAGCGTCTTTCGGGATTGCTGCTGATTTCTCCGGCGGGCGGCTACGGCGGCGCACCCGCC
GACGTGCGGGCCGAGCGGCGCGACAGCCGCCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCAAACATGCTGTCCGCGCAGGCGAGCGACGCCGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCCG
GCTATGCGCAGGCGACGCACCTGCTCGCGAACGCGGACCTCGCTTCCGATCTCGCGCATTATCGCGGCCGCGTCGCGGTC
GCGGTCGGCGCCGACGATACGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGCGGGCAGCGGGCGCCGGGTTGCAGGT
GATCCCGCGCGCGGGCCATGCCGGCTATGTCGAAGCGCCGGATGCATACAACGCGTTGATCGACGCATTTTGCCGTCAAT
GCGACGGATCGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT47915 WP_009897321.1 NZ_CP008915:817843-818697 [Burkholderia thailandensis]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT47915 NZ_CP008915:817843-818697 [Burkholderia thailandensis]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGCGCAACGATTCGAACTACGTCGTGCCTGGGCTCGAGCGCGGGCT
GCGGATCCTCGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTGGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGTTTGCCGGTGATCGAGGG
CTTGCGCGACGCGACGGGCTTCACGGCGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACTTGACGCTCGCCGAGTTGCGCACGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGATGCGCTGTTCGACGTGATCCGTGCCGACGCGCGCCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCAGTCGTCACGGTGACGGTGCCGAGG
CCGGAGATCGATGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTCGTGCGTGCGGCGGCCGAGCTGTCTCGGCGGCT
CAATTACCGGTCCGACGACGAAAACACCTACTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ2T555

Antitoxin

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Source
ID
Structure
AlphaFold DBQ2T556

References