47914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1986616..1987153 Replicon chromosome
Accession NZ_CP008912
Organism Burkholderia pseudomallei HBPUB10134a

Toxin (Protein)


Gene name brnT Uniprot ID A0A0F6L9W9
Locus tag DR55_RS25635 Protein ID WP_009971435.1
Coordinates 1986884..1987153 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag DR55_RS25630 Protein ID WP_004525420.1
Coordinates 1986616..1986900 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR55_RS25605 1981724..1982986 - 1263 WP_004551329.1 c-type cytochrome -
DR55_RS25610 1983145..1984605 - 1461 WP_011326543.1 metallophosphoesterase -
DR55_RS25615 1984852..1984968 + 117 Protein_1563 IS3 family transposase -
DR55_RS36635 1985195..1985623 - 429 Protein_1564 IS110 family transposase -
DR55_RS36640 1985586..1985969 - 384 Protein_1565 DDE-type integrase/transposase/recombinase -
DR55_RS25630 1986616..1986900 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
DR55_RS25635 1986884..1987153 - 270 WP_009971435.1 BrnT family toxin Toxin
DR55_RS25640 1987706..1987981 + 276 WP_025988352.1 hypothetical protein -
DR55_RS25655 1988258..1988479 + 222 WP_004538072.1 hypothetical protein -
DR55_RS40095 1988446..1988745 + 300 WP_162482191.1 hypothetical protein -
DR55_RS25665 1988976..1989557 - 582 WP_004542548.1 hypothetical protein -
DR55_RS25670 1989816..1989965 + 150 WP_004537646.1 bacteriophage protein Gp44 -
DR55_RS40535 1989962..1990735 + 774 Protein_1573 prohibitin family protein -
DR55_RS40540 1990733..1991161 + 429 Protein_1574 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1979502..1993472 13970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10143.43 Da        Isoelectric Point: 5.6831

>T47914 WP_009971435.1 NZ_CP008912:c1987153-1986884 [Burkholderia pseudomallei HBPUB10134a]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVVGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T47914 NZ_CP008912:c1987153-1986884 [Burkholderia pseudomallei HBPUB10134a]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGGTCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT47914 WP_004525420.1 NZ_CP008912:c1986900-1986616 [Burkholderia pseudomallei HBPUB10134a]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT47914 NZ_CP008912:c1986900-1986616 [Burkholderia pseudomallei HBPUB10134a]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGCCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGTTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6L9W9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References