Detailed information of TA system TA047906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 391112..391767
• Replicon: chromosome
• Accession: NZ_CP008910
• Organism: Burkholderia pseudomallei MSHR5848

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DP65_RS19820
• Protein ID: WP_004521942.1
• Coordinates: 391471..391767 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q63YL3
• Locus tag: DP65_RS19815
• Protein ID: WP_004202809.1
• Coordinates: 391112..391468 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DP65_RS19795	386247..387260	-	1014	WP_024429662.1	phage major capsid protein, P2 family	-
DP65_RS19800	387294..388103	-	810	WP_015985028.1	GPO family capsid scaffolding protein	-
DP65_RS19805	388247..390016	+	1770	WP_024429661.1	terminase ATPase subunit family protein	-
DP65_RS19810	390013..391068	+	1056	WP_038789201.1	phage portal protein	-
DP65_RS19815	391112..391468	-	357	WP_004202809.1	putative addiction module antidote protein	Antitoxin
DP65_RS19820	391471..391767	-	297	WP_004521942.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DP65_RS35775	392399..393112	-	714	WP_080002914.1	cellulose biosynthesis protein BcsS	-
DP65_RS19825	393039..395288	-	2250	WP_009979045.1	glycosyltransferase	-
DP65_RS19830	395399..396763	-	1365	WP_051781513.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	366585..406747	40162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (16-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10902.68 Da
• Isoelectric Point: 9.9369

>T47906 WP_004521942.1 NZ_CP008910:c391767-391471 [Burkholderia pseudomallei MSHR5848]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIADELED

Nucleotide

• Length: 297 bp

>T47906 NZ_CP008910:c391767-391471 [Burkholderia pseudomallei MSHR5848]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGACGAACTGGAGGATTGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12585.41 Da
• Isoelectric Point: 9.9470

>AT47906 WP_004202809.1 NZ_CP008910:c391468-391112 [Burkholderia pseudomallei MSHR5848]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Nucleotide

• Length: 357 bp

>AT47906 NZ_CP008910:c391468-391112 [Burkholderia pseudomallei MSHR5848]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3N4G1D3