Detailed information of TA system TA047905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2473500..2474056
• Replicon: chromosome
• Accession: NZ_CP008909
• Organism: Burkholderia pseudomallei MSHR5848

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DP65_RS11190
• Protein ID: WP_024429387.1
• Coordinates: 2473766..2474056 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: DP65_RS11185
• Protein ID: WP_004541313.1
• Coordinates: 2473500..2473778 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DP65_RS39580	2469018..2470298	+	1281	WP_144399190.1	hypothetical protein	-
DP65_RS34010	2470345..2470635	-	291	WP_071897845.1	hypothetical protein	-
DP65_RS11170	2471124..2471393	+	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
DP65_RS11180	2471396..2473420	+	2025	WP_075018821.1	relaxase/mobilization nuclease domain-containing protein	-
DP65_RS11185	2473500..2473778	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
DP65_RS11190	2473766..2474056	+	291	WP_024429387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DP65_RS11195	2474053..2474373	+	321	WP_024429388.1	hypothetical protein	-
DP65_RS39585	2474569..2474817	+	249	WP_080251141.1	hypothetical protein	-
DP65_RS41345	2474922..2475581	+	660	WP_024429389.1	hypothetical protein	-
DP65_RS11205	2475623..2477827	-	2205	WP_024429390.1	AAA family ATPase	-
DP65_RS11210	2478054..2478575	-	522	WP_024429391.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2460938..2482922	21984

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10906.47 Da
• Isoelectric Point: 9.5554

>T47905 WP_024429387.1 NZ_CP008909:2473766-2474056 [Burkholderia pseudomallei MSHR5848]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T47905 NZ_CP008909:2473766-2474056 [Burkholderia pseudomallei MSHR5848]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT47905 WP_004541313.1 NZ_CP008909:2473500-2473778 [Burkholderia pseudomallei MSHR5848]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT47905 NZ_CP008909:2473500-2473778 [Burkholderia pseudomallei MSHR5848]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0