Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4583074..4583690 Replicon chromosome
Accession NZ_CP008905
Organism Enterobacter hormaechei subsp. hoffmannii ECR091

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ECR091_RS21690 Protein ID WP_080298797.1
Coordinates 4583074..4583445 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag ECR091_RS21695 Protein ID WP_023298920.1
Coordinates 4583448..4583690 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECR091_RS21675 4580574..4581476 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
ECR091_RS21680 4581473..4582108 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
ECR091_RS21685 4582105..4583034 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
ECR091_RS21690 4583074..4583445 - 372 WP_080298797.1 type II toxin-antitoxin system VapC family toxin Toxin
ECR091_RS21695 4583448..4583690 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
ECR091_RS21700 4583890..4584810 + 921 WP_038416944.1 alpha/beta hydrolase -
ECR091_RS21705 4584819..4585760 - 942 WP_038416946.1 fatty acid biosynthesis protein FabY -
ECR091_RS21710 4585805..4586242 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
ECR091_RS21715 4586239..4587120 - 882 WP_023298923.1 virulence factor BrkB family protein -
ECR091_RS21720 4587114..4587713 - 600 WP_023315056.1 glucose-1-phosphatase -
ECR091_RS21725 4587832..4588632 - 801 WP_038416949.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.66 Da        Isoelectric Point: 6.4865

>T47900 WP_080298797.1 NZ_CP008905:c4583445-4583074 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T47900 NZ_CP008905:c4583445-4583074 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGGAGCACATGGCTGTGTATGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGGGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT47900 WP_023298920.1 NZ_CP008905:c4583690-4583448 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT47900 NZ_CP008905:c4583690-4583448 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References