Detailed information of TA system TA047899

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3742719..3743376
• Replicon: chromosome
• Accession: NZ_CP008905
• Organism: Enterobacter hormaechei subsp. hoffmannii ECR091

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ECR091_RS17650
• Protein ID: WP_038416677.1
• Coordinates: 3742719..3743129 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: ECR091_RS17655
• Protein ID: WP_003863437.1
• Coordinates: 3743110..3743376 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECR091_RS17630	3738717..3740450	-	1734	WP_038416675.1	single-stranded-DNA-specific exonuclease RecJ	-
ECR091_RS17635	3740456..3741169	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ECR091_RS17640	3741198..3742094	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
ECR091_RS17645	3742196..3742717	+	522	WP_023306886.1	flavodoxin FldB	-
ECR091_RS17650	3742719..3743129	-	411	WP_038416677.1	protein YgfX	Toxin
ECR091_RS17655	3743110..3743376	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
ECR091_RS17660	3743671..3744651	+	981	WP_038416679.1	tRNA-modifying protein YgfZ	-
ECR091_RS17665	3744737..3745396	-	660	WP_022649307.1	hemolysin III family protein	-
ECR091_RS17675	3745663..3746394	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-
ECR091_RS17680	3746511..3747944	+	1434	WP_038416681.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16337.20 Da
• Isoelectric Point: 11.4775

>T47899 WP_038416677.1 NZ_CP008905:c3743129-3742719 [Enterobacter hormaechei subsp. hoffmannii ECR091]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINSRQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T47899 NZ_CP008905:c3743129-3742719 [Enterobacter hormaechei subsp. hoffmannii ECR091]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACTCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT47899 WP_003863437.1 NZ_CP008905:c3743376-3743110 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT47899 NZ_CP008905:c3743376-3743110 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5