Detailed information of TA system TA047898

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3500304..3501037
• Replicon: chromosome
• Accession: NZ_CP008905
• Organism: Enterobacter hormaechei subsp. hoffmannii ECR091

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: ECR091_RS24260
• Protein ID: WP_043491403.1
• Coordinates: 3500708..3501037 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: ECR091_RS16440
• Protein ID: WP_038416562.1
• Coordinates: 3500304..3500669 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECR091_RS25415	3495563..3495712	+	150	WP_001458941.1	hypothetical protein	-
ECR091_RS16400	3495724..3495939	+	216	WP_038416553.1	hypothetical protein	-
ECR091_RS16405	3496084..3496494	+	411	WP_038416555.1	hypothetical protein	-
ECR091_RS24915	3496560..3497498	+	939	WP_077887331.1	hypothetical protein	-
ECR091_RS16415	3497572..3497805	+	234	WP_038416556.1	DUF905 domain-containing protein	-
ECR091_RS16420	3497919..3498737	+	819	WP_038416557.1	DUF945 domain-containing protein	-
ECR091_RS24255	3498737..3498991	+	255	WP_071881512.1	hypothetical protein	-
ECR091_RS16425	3499088..3499555	+	468	WP_038416558.1	antirestriction protein	-
ECR091_RS16430	3499566..3500045	+	480	WP_043491407.1	DNA repair protein RadC	-
ECR091_RS16435	3500057..3500278	+	222	WP_038416561.1	DUF987 family protein	-
ECR091_RS16440	3500304..3500669	+	366	WP_038416562.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ECR091_RS24260	3500708..3501037	+	330	WP_043491403.1	TA system toxin CbtA family protein	Toxin
ECR091_RS16445	3501407..3502405	+	999	Protein_3225	integrase arm-type DNA-binding domain-containing protein	-
ECR091_RS24920	3503551..3503724	-	174	WP_080298784.1	chromosome partitioning protein ParA	-
ECR091_RS16465	3503721..3505301	-	1581	WP_038416563.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3494854..3519111	24257

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12384.08 Da
• Isoelectric Point: 6.8692

>T47898 WP_043491403.1 NZ_CP008905:3500708-3501037 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MQTLSLHPTRATPLCLSPVETWQRLLAHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDREGF
SWQEQTPYISAVDILRARRSTGLLKTDVK

Nucleotide

• Length: 330 bp

>T47898 NZ_CP008905:3500708-3501037 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGCAAACTTTATCATTACACCCGACTCGGGCGACTCCGCTCTGTTTGTCACCCGTTGAAACCTGGCAACGGCTACTGGC
TCATCTGTTCTCGCAGCACTATGGCCTGACGCTGAATGACACACCATTCAGTAATGAAACCACCATCCGGGAACATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGACTTGTTCGTATCGACCGGGAGGGATTT
TCATGGCAAGAGCAAACTCCGTATATTTCCGCAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTGA
CGTGAAATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13509.23 Da
• Isoelectric Point: 4.7952

>AT47898 WP_038416562.1 NZ_CP008905:3500304-3500669 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MNNHSESGTKPENPACKQWGLRCTITPCFGARLVQEGNRVHFLADRAGFNGAFSDEDVLRLDQAFSLILKQLELMLTSGE
LNPLYQHCVTLYHNGLTCEADTLGSFGYVYIAIYPDQPEPQ

Nucleotide

• Length: 366 bp

>AT47898 NZ_CP008905:3500304-3500669 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGAACAATCACTCCGAATCCGGAACTAAGCCGGAGAATCCCGCCTGCAAGCAGTGGGGACTAAGGTGCACGATCACACC
CTGTTTTGGCGCTCGCCTAGTGCAGGAGGGCAACCGGGTGCATTTTCTCGCTGATCGGGCCGGATTCAACGGTGCTTTCA
GTGACGAGGATGTGTTACGCCTAGACCAAGCTTTTTCACTGATACTCAAGCAACTGGAGCTAATGCTCACCAGCGGCGAG
CTAAATCCCCTCTATCAGCACTGCGTCACGCTTTACCACAACGGGCTCACCTGCGAAGCCGATACACTGGGCTCCTTTGG
TTATGTCTACATTGCTATTTATCCTGACCAGCCTGAACCGCAGTAA