Detailed information of TA system TA047888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2257110..2257849
• Replicon: chromosome
• Accession: NZ_CP008905
• Organism: Enterobacter hormaechei subsp. hoffmannii ECR091

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: ECR091_RS10640
• Protein ID: WP_038416064.1
• Coordinates: 2257110..2257595 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: ECR091_RS10645
• Protein ID: WP_003857131.1
• Coordinates: 2257583..2257849 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECR091_RS10620	2252997..2253755	-	759	WP_032624253.1	trans-aconitate 2-methyltransferase	-
ECR091_RS10625	2253840..2254424	-	585	WP_022648128.1	NUDIX hydrolase	-
ECR091_RS10630	2254511..2255269	+	759	WP_022648129.1	DeoR/GlpR family DNA-binding transcription regulator	-
ECR091_RS10635	2255374..2256666	+	1293	WP_038416063.1	glycoside hydrolase	-
ECR091_RS10640	2257110..2257595	-	486	WP_038416064.1	GNAT family N-acetyltransferase	Toxin
ECR091_RS10645	2257583..2257849	-	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
ECR091_RS10650	2257913..2258842	-	930	WP_038416065.1	LysR family transcriptional regulator	-
ECR091_RS10655	2258972..2260360	+	1389	WP_038416066.1	MFS transporter	-
ECR091_RS10660	2260339..2260896	-	558	WP_023300131.1	OmpH family outer membrane protein	-
ECR091_RS10665	2261017..2262153	-	1137	WP_038416067.1	type 1 fimbrial protein	-
ECR091_RS10670	2262177..2262701	-	525	WP_087878309.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2243269..2257849	14580

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17546.28 Da
• Isoelectric Point: 9.9308

>T47888 WP_038416064.1 NZ_CP008905:c2257595-2257110 [Enterobacter hormaechei subsp. hoffmannii ECR091]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALAAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGKGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T47888 NZ_CP008905:c2257595-2257110 [Enterobacter hormaechei subsp. hoffmannii ECR091]
GTGGGACGTGTAACCGCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGCCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAAAGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT47888 WP_003857131.1 NZ_CP008905:c2257849-2257583 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT47888 NZ_CP008905:c2257849-2257583 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9