Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1093648..1094269 Replicon chromosome
Accession NZ_CP008905
Organism Enterobacter hormaechei subsp. hoffmannii ECR091

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag ECR091_RS05175 Protein ID WP_015571250.1
Coordinates 1093648..1093866 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag ECR091_RS05180 Protein ID WP_006809850.1
Coordinates 1093895..1094269 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECR091_RS05145 1089660..1089920 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
ECR091_RS05150 1089923..1090063 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ECR091_RS05155 1090060..1090770 - 711 WP_038415530.1 GNAT family N-acetyltransferase -
ECR091_RS05160 1090873..1092333 + 1461 WP_038415532.1 PLP-dependent aminotransferase family protein -
ECR091_RS05165 1092305..1092772 - 468 WP_022647269.1 hypothetical protein -
ECR091_RS05170 1092889..1093440 - 552 WP_022647270.1 maltose O-acetyltransferase -
ECR091_RS05175 1093648..1093866 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
ECR091_RS05180 1093895..1094269 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
ECR091_RS05185 1094779..1097925 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
ECR091_RS05190 1097948..1099141 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T47887 WP_015571250.1 NZ_CP008905:c1093866-1093648 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T47887 NZ_CP008905:c1093866-1093648 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT47887 WP_006809850.1 NZ_CP008905:c1094269-1093895 [Enterobacter hormaechei subsp. hoffmannii ECR091]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT47887 NZ_CP008905:c1094269-1093895 [Enterobacter hormaechei subsp. hoffmannii ECR091]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References