Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4595096..4595712 | Replicon | chromosome |
Accession | NZ_CP008897 | ||
Organism | Enterobacter hormaechei subsp. hoffmannii ECNIH3 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | ECNIH3_RS21740 | Protein ID | WP_080298797.1 |
Coordinates | 4595096..4595467 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A9E7BIL4 |
Locus tag | ECNIH3_RS21745 | Protein ID | WP_023298920.1 |
Coordinates | 4595470..4595712 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ECNIH3_RS21725 | 4592596..4593498 | + | 903 | WP_003861960.1 | formate dehydrogenase subunit beta | - |
ECNIH3_RS21730 | 4593495..4594130 | + | 636 | WP_006808711.1 | formate dehydrogenase cytochrome b556 subunit | - |
ECNIH3_RS21735 | 4594127..4595056 | + | 930 | WP_022649835.1 | formate dehydrogenase accessory protein FdhE | - |
ECNIH3_RS21740 | 4595096..4595467 | - | 372 | WP_080298797.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
ECNIH3_RS21745 | 4595470..4595712 | - | 243 | WP_023298920.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
ECNIH3_RS21750 | 4595912..4596832 | + | 921 | WP_038416944.1 | alpha/beta hydrolase | - |
ECNIH3_RS21755 | 4596841..4597782 | - | 942 | WP_038416946.1 | fatty acid biosynthesis protein FabY | - |
ECNIH3_RS21760 | 4597827..4598264 | - | 438 | WP_015569909.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
ECNIH3_RS21765 | 4598261..4599142 | - | 882 | WP_023298923.1 | virulence factor BrkB family protein | - |
ECNIH3_RS21770 | 4599136..4599735 | - | 600 | WP_023315056.1 | glucose-1-phosphatase | - |
ECNIH3_RS21775 | 4599854..4600654 | - | 801 | WP_038416949.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13612.66 Da Isoelectric Point: 6.4865
>T47884 WP_080298797.1 NZ_CP008897:c4595467-4595096 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL
Download Length: 372 bp
>T47884 NZ_CP008897:c4595467-4595096 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
ATGGAGCACATGGCTGTGTATGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGGGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG
ATGGAGCACATGGCTGTGTATGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGGGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9467.74 Da Isoelectric Point: 4.3775
>AT47884 WP_023298920.1 NZ_CP008897:c4595712-4595470 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW
Download Length: 243 bp
>AT47884 NZ_CP008897:c4595712-4595470 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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