Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4595096..4595712 Replicon chromosome
Accession NZ_CP008897
Organism Enterobacter hormaechei subsp. hoffmannii ECNIH3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ECNIH3_RS21740 Protein ID WP_080298797.1
Coordinates 4595096..4595467 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag ECNIH3_RS21745 Protein ID WP_023298920.1
Coordinates 4595470..4595712 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECNIH3_RS21725 4592596..4593498 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
ECNIH3_RS21730 4593495..4594130 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
ECNIH3_RS21735 4594127..4595056 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
ECNIH3_RS21740 4595096..4595467 - 372 WP_080298797.1 type II toxin-antitoxin system VapC family toxin Toxin
ECNIH3_RS21745 4595470..4595712 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
ECNIH3_RS21750 4595912..4596832 + 921 WP_038416944.1 alpha/beta hydrolase -
ECNIH3_RS21755 4596841..4597782 - 942 WP_038416946.1 fatty acid biosynthesis protein FabY -
ECNIH3_RS21760 4597827..4598264 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
ECNIH3_RS21765 4598261..4599142 - 882 WP_023298923.1 virulence factor BrkB family protein -
ECNIH3_RS21770 4599136..4599735 - 600 WP_023315056.1 glucose-1-phosphatase -
ECNIH3_RS21775 4599854..4600654 - 801 WP_038416949.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-114)

Antitoxin

(12-49)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.66 Da        Isoelectric Point: 6.4865

>T47884 WP_080298797.1 NZ_CP008897:c4595467-4595096 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T47884 NZ_CP008897:c4595467-4595096 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
ATGGAGCACATGGCTGTGTATGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGGGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT47884 WP_023298920.1 NZ_CP008897:c4595712-4595470 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT47884 NZ_CP008897:c4595712-4595470 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References