Detailed information of TA system TA047883

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3754742..3755399
• Replicon: chromosome
• Accession: NZ_CP008897
• Organism: Enterobacter hormaechei subsp. hoffmannii ECNIH3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ECNIH3_RS17705
• Protein ID: WP_038416677.1
• Coordinates: 3754742..3755152 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: ECNIH3_RS17710
• Protein ID: WP_003863437.1
• Coordinates: 3755133..3755399 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECNIH3_RS17685	3750740..3752473	-	1734	WP_038416675.1	single-stranded-DNA-specific exonuclease RecJ	-
ECNIH3_RS17690	3752479..3753192	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ECNIH3_RS17695	3753221..3754117	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
ECNIH3_RS17700	3754219..3754740	+	522	WP_023306886.1	flavodoxin FldB	-
ECNIH3_RS17705	3754742..3755152	-	411	WP_038416677.1	protein YgfX	Toxin
ECNIH3_RS17710	3755133..3755399	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
ECNIH3_RS17715	3755694..3756674	+	981	WP_038416679.1	tRNA-modifying protein YgfZ	-
ECNIH3_RS17720	3756760..3757419	-	660	WP_022649307.1	hemolysin III family protein	-
ECNIH3_RS17730	3757686..3758417	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-
ECNIH3_RS17735	3758534..3759967	+	1434	WP_038416681.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16337.20 Da
• Isoelectric Point: 11.4775

>T47883 WP_038416677.1 NZ_CP008897:c3755152-3754742 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINSRQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T47883 NZ_CP008897:c3755152-3754742 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACTCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT47883 WP_003863437.1 NZ_CP008897:c3755399-3755133 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT47883 NZ_CP008897:c3755399-3755133 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5