47869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 4799814..4800345 Replicon chromosome
Accession NZ_CP008896
Organism Pseudomonas fluorescens strain UK4

Toxin (Protein)


Gene name relE Uniprot ID W2D823
Locus tag HZ99_RS21415 Protein ID WP_011282522.1
Coordinates 4799814..4800095 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID W2D9V6
Locus tag HZ99_RS21420 Protein ID WP_020303033.1
Coordinates 4800082..4800345 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ99_RS21400 4797632..4799257 + 1626 WP_020301382.1 methyl-accepting chemotaxis protein -
HZ99_RS21405 4799347..4799594 - 248 Protein_4268 hypothetical protein -
HZ99_RS21410 4799594..4799778 - 185 Protein_4269 hypothetical protein -
HZ99_RS21415 4799814..4800095 - 282 WP_011282522.1 type II toxin-antitoxin system YafQ family toxin Toxin
HZ99_RS21420 4800082..4800345 - 264 WP_020303033.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZ99_RS21425 4800516..4801412 - 897 WP_085986662.1 cation diffusion facilitator family transporter -
HZ99_RS21430 4801510..4801917 + 408 WP_024015046.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
HZ99_RS21435 4802048..4802395 + 348 WP_024015047.1 DUF3703 domain-containing protein -
HZ99_RS21440 4802392..4802901 + 510 WP_003452327.1 lipoprotein signal peptidase -
HZ99_RS21445 4802901..4803647 + 747 WP_024015048.1 AraC family transcriptional regulator -
HZ99_RS21450 4803716..4804582 + 867 WP_024015049.1 sterol desaturase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4804853..4806397 1544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10710.20 Da        Isoelectric Point: 9.6866

>T47869 WP_011282522.1 NZ_CP008896:c4800095-4799814 [Pseudomonas fluorescens]
MRTIEQTSRFKRDYKREAKGPHRQTLASDFIAVVTALANNQPLAEKHRDHALTGDWKDHRDCHIKPDLVLIYRKPDDAVL
QLVRLGSHSELGL

Download         Length: 282 bp

>T47869 NZ_CP008896:c4800095-4799814 [Pseudomonas fluorescens]
ATGCGGACGATTGAACAGACCAGCCGGTTCAAACGCGATTATAAACGCGAAGCCAAAGGCCCGCATCGTCAGACGCTGGC
GAGCGATTTCATTGCCGTCGTCACAGCCCTGGCGAATAACCAGCCTCTGGCCGAGAAGCACCGTGACCACGCCCTCACCG
GCGACTGGAAAGACCACCGGGACTGTCACATCAAGCCCGACCTGGTGTTGATTTACCGCAAGCCGGATGACGCCGTGCTG
CAACTCGTGCGTCTCGGATCGCATAGCGAGCTTGGCCTGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9471.95 Da        Isoelectric Point: 4.8096

>AT47869 WP_020303033.1 NZ_CP008896:c4800345-4800082 [Pseudomonas fluorescens]
MSANAVVRARIDEHIKEEATVVLAAMGLTVSDAFRIMLTRVAREKALPFEPLIPNATTIEAMKEARRGGLKSFASVEDLM
ADLNADD

Download         Length: 264 bp

>AT47869 NZ_CP008896:c4800345-4800082 [Pseudomonas fluorescens]
ATGTCCGCAAATGCTGTAGTCCGTGCCCGTATCGACGAGCACATCAAGGAAGAGGCGACCGTCGTGCTGGCAGCGATGGG
ACTCACCGTGTCTGACGCCTTCCGCATCATGTTGACCCGAGTCGCCCGCGAGAAAGCCTTGCCGTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCGCGCCGTGGCGGCTTGAAGTCGTTCGCTTCCGTCGAGGATCTGATG
GCGGATCTGAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N2T9

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0N2R7

References