Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 4763981..4764573 Replicon chromosome
Accession NZ_CP008896
Organism Pseudomonas fluorescens strain UK4

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HZ99_RS21250 Protein ID WP_038445845.1
Coordinates 4763981..4764283 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HZ99_RS21255 Protein ID WP_038445848.1
Coordinates 4764280..4764573 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ99_RS21220 4759663..4761342 - 1680 WP_003465068.1 DDE-type integrase/transposase/recombinase -
HZ99_RS21225 4761864..4762235 - 372 WP_038445836.1 hypothetical protein -
HZ99_RS21230 4762297..4762482 - 186 WP_090412651.1 hypothetical protein -
HZ99_RS21235 4762529..4762981 - 453 WP_038445839.1 hypothetical protein -
HZ99_RS21245 4763449..4763805 - 357 WP_038445844.1 hypothetical protein -
HZ99_RS21250 4763981..4764283 + 303 WP_038445845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZ99_RS21255 4764280..4764573 + 294 WP_038445848.1 putative addiction module antidote protein Antitoxin
HZ99_RS27430 4765114..4765719 - 606 WP_051903205.1 hypothetical protein -
HZ99_RS21265 4765758..4766060 - 303 WP_038445850.1 hypothetical protein -
HZ99_RS21270 4766191..4766619 - 429 WP_038445851.1 hypothetical protein -
HZ99_RS21275 4766676..4767512 - 837 WP_038445853.1 DUF945 domain-containing protein -
HZ99_RS21280 4768313..4769356 - 1044 WP_051903207.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-90)

Antitoxin

Uncharacterized protein HI1420

(6-95)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11125.74 Da        Isoelectric Point: 9.8909

>T47868 WP_038445845.1 NZ_CP008896:4763981-4764283 [Pseudomonas fluorescens]
MKTIKQTATFRTWESKLKDRTAKAAIAARIIRVANGLMGDVSPVGQGVSELRIHYGPGYRVYFQQRGDELVILLCGGDKA
TQSRDIETAKILAKDWSDNE

Download         Length: 303 bp

>T47868 NZ_CP008896:4763981-4764283 [Pseudomonas fluorescens]
ATGAAAACGATCAAACAAACCGCGACGTTTCGCACTTGGGAAAGCAAGCTCAAAGACCGGACCGCAAAGGCCGCGATTGC
CGCTCGGATCATCCGGGTAGCAAACGGACTGATGGGGGATGTTTCCCCAGTTGGTCAAGGCGTTAGCGAGTTGCGTATTC
ACTATGGGCCGGGGTATCGGGTGTATTTTCAGCAGCGCGGCGATGAGCTGGTAATTTTGCTGTGCGGAGGCGATAAGGCC
ACGCAATCCCGCGATATTGAGACGGCTAAAATCCTTGCAAAAGATTGGAGCGACAATGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10432.04 Da        Isoelectric Point: 5.6863

>AT47868 WP_038445848.1 NZ_CP008896:4764280-4764573 [Pseudomonas fluorescens]
MKEPLYDYDPAAALVDPETIAVFMADAFETGDAGHIAKALGIVARAKGMTEIAKESGLSREMLYRSFSEKGNPTLKTMLA
VMRAVGVDMTARQHAPS

Download         Length: 294 bp

>AT47868 NZ_CP008896:4764280-4764573 [Pseudomonas fluorescens]
ATGAAAGAGCCACTTTATGACTACGACCCAGCGGCGGCGCTGGTTGATCCTGAAACCATTGCCGTGTTCATGGCTGACGC
CTTTGAAACTGGTGACGCGGGCCACATCGCTAAAGCGCTCGGCATAGTTGCCAGAGCCAAGGGCATGACCGAAATTGCCA
AGGAATCCGGCCTGTCCCGCGAGATGCTTTATCGGTCATTCAGCGAGAAAGGGAACCCCACGCTGAAAACCATGTTGGCC
GTGATGCGCGCCGTTGGTGTGGATATGACAGCCCGTCAGCACGCCCCTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References