Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 792155..792786 Replicon chromosome
Accession NZ_CP008887
Organism Thermococcus eurythermalis strain A501

Toxin (Protein)


Gene name vapC Uniprot ID A0A097QT09
Locus tag TEU_RS04140 Protein ID WP_050002589.1
Coordinates 792379..792786 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A097QT23
Locus tag TEU_RS04135 Protein ID WP_050002588.1
Coordinates 792155..792391 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TEU_RS04110 (TEU_04175) 787440..787709 - 270 WP_050002583.1 (2Fe-2S)-binding protein -
TEU_RS04115 (TEU_04180) 787711..788220 - 510 WP_050002584.1 4Fe-4S binding protein -
TEU_RS04120 (TEU_04185) 788217..789653 - 1437 WP_050002585.1 FAD-dependent oxidoreductase -
TEU_RS04125 (TEU_04190) 790139..791137 + 999 WP_050002586.1 pyridoxal-phosphate dependent enzyme -
TEU_RS04130 (TEU_04195) 791175..792074 + 900 WP_174412704.1 dihydroorotate dehydrogenase -
TEU_RS04135 (TEU_04200) 792155..792391 + 237 WP_050002588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
TEU_RS04140 (TEU_04205) 792379..792786 + 408 WP_050002589.1 PIN domain-containing protein Toxin
TEU_RS04145 (TEU_04210) 792786..793505 + 720 WP_050002590.1 7-cyano-7-deazaguanine synthase QueC -
TEU_RS04150 (TEU_04215) 793570..793791 + 222 WP_227738765.1 hypothetical protein -
TEU_RS04175 (TEU_04240) 794752..795360 + 609 WP_050002591.1 SMC-Scp complex subunit ScpB -
TEU_RS04180 (TEU_04245) 795477..796547 + 1071 WP_050002592.1 OB-fold nucleic acid binding domain-containing protein -
TEU_RS04185 (TEU_04250) 796549..796926 + 378 WP_050002593.1 replication protein RepA -
TEU_RS04190 (TEU_04255) 796923..797729 + 807 WP_050002594.1 OB-fold nucleic acid binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(5-44)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15489.12 Da        Isoelectric Point: 7.2014

>T47861 WP_050002589.1 NZ_CP008887:792379-792786 [Thermococcus eurythermalis]
MERVAVVDTNVLIYSINRSSEKYVEARDLIHSLDRIVLPTIVVYEFIWNLAVVGVVPQEAEKTLSQILLNERVVLADDRK
YLLSAFELFENFSLKHYNDSVILAIAKEKGTLATYDKKLRKRAEKLGIKLLPEVI

Download         Length: 408 bp

>T47861 NZ_CP008887:792379-792786 [Thermococcus eurythermalis]
ATGGAAAGAGTAGCCGTCGTGGACACGAACGTGCTCATTTACTCAATCAACAGAAGCTCTGAGAAGTACGTAGAAGCAAG
GGACCTCATACATTCCCTCGACAGAATCGTCCTGCCGACGATTGTGGTATACGAGTTCATATGGAATCTCGCAGTAGTGG
GCGTTGTCCCTCAAGAAGCCGAAAAAACACTATCACAAATCCTCCTAAACGAAAGAGTAGTGCTCGCAGACGACAGAAAA
TACTTGCTTTCGGCATTTGAACTCTTTGAGAACTTCAGCCTCAAGCACTACAACGACTCCGTAATCCTCGCGATAGCTAA
AGAGAAGGGAACCCTTGCGACCTACGACAAAAAGCTTAGAAAGCGTGCGGAAAAACTGGGGATTAAACTGCTTCCGGAGG
TGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9112.50 Da        Isoelectric Point: 5.2206

>AT47861 WP_050002588.1 NZ_CP008887:792155-792391 [Thermococcus eurythermalis]
MPITKVTRNYQITIPAEIRKALGIKQGEYLTVELRGDEIVIRKAEVEWPSLDLGRDFTPEEIEKNTEKILREASKWKE

Download         Length: 237 bp

>AT47861 NZ_CP008887:792155-792391 [Thermococcus eurythermalis]
ATGCCGATAACGAAGGTGACCCGGAACTACCAGATAACGATTCCGGCCGAGATTAGGAAGGCCCTTGGCATAAAGCAGGG
CGAATACCTCACAGTTGAGCTGAGGGGAGATGAGATCGTCATAAGGAAGGCCGAGGTAGAGTGGCCAAGCCTTGATCTTG
GCAGGGACTTTACACCGGAAGAAATTGAGAAGAACACTGAAAAGATTCTCAGGGAGGCTTCCAAATGGAAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QT09

Antitoxin

Source ID Structure
AlphaFold DB A0A097QT23

References