Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2552545..2554148 Replicon chromosome
Accession NZ_CP008886
Organism Raoultella ornithinolytica strain A14

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag HY59_RS11820 Protein ID WP_015584335.1
Coordinates 2552817..2554148 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag HY59_RS11815 Protein ID WP_032717448.1
Coordinates 2552545..2552817 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HY59_RS11790 2548165..2549406 + 1242 WP_004861912.1 sensor domain-containing diguanylate cyclase -
HY59_RS11795 2549426..2550058 + 633 WP_048023555.1 class I SAM-dependent methyltransferase -
HY59_RS11800 2550272..2551225 + 954 WP_004861921.1 hypothetical protein -
HY59_RS11805 2551357..2551782 + 426 WP_032724724.1 hypothetical protein -
HY59_RS11810 2551788..2552342 + 555 WP_064357055.1 RNA polymerase sigma factor -
HY59_RS11815 2552545..2552817 + 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HY59_RS11820 2552817..2554148 + 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
HY59_RS11825 2554081..2555496 - 1416 WP_099144431.1 glycoside hydrolase family 10 protein -
HY59_RS11830 2556202..2557260 + 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
HY59_RS11835 2557360..2558274 + 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T47849 WP_015584335.1 NZ_CP008886:2552817-2554148 [Raoultella ornithinolytica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

>T47849 NZ_CP008886:2552817-2554148 [Raoultella ornithinolytica]
ATGGCGACTCTCGTGACATGGATGAACAATGAGCGGGTCGGCGAGCTAATCAAGCAGGCGAACGGCGCACATCTCTTTCG
CTATGAAGAGGCGTGGATGCGCAATCCTCGCGCCAGACCGCTCTCACTGTCGCTTCCGCTGCAGTACGGTAACATCACCG
ACGAGGCGGTATTTAACTACTTTGACAATCTGCTGCCGGACAGTCCGCGGGTACGGGACCGCATTGTTAAGCGCTATCAG
GCGCGTTCAAAGCAGCCGTTTGATCTGCTGGCCGAGATCGGACGGGACAGCGTCGGGGCGGTAACGTTACTCCCGCCAGG
AGAAAATGCGCCCCGCGGGGCGTTGAGCTGGGAGCCGCTGGATAACCACGCTCTGGATGCGTTACTGACGGCCTACCAGT
CGGATATACCGCTCGGAATGGTCAACGAACACGATGATTTCAGGATCTCGGTGGCCGGGGCCCAGGAGAAAACCGCGCTG
CTGAAAATCGGCGAGCAGTGGTGTATCCCGACGGGTACCACGCCGACTACCCACATCATTAAACTGCCCATCGGCGAGAT
CAAACAGCCGGATGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATTTGTGTCTGGCGCTGGCCCGGGCGCTGG
GTTTTGCCGTTCCGCCCGCCAGCATTATCCAGACAGCCAGTATCAGGGCGCTGGCGGTGGAGCGTTTCGACCGTCGCTGG
GCGCAGGAGAAAACGGTGCTGCTGCGTTTGCCGCAGGAAGATCTGTGTCAGGCCTTCGGCATTCCGTCATCGATTAAGTA
TGAGTCCGACGGCGGGCCGGGCATTCGGGCAATTATGGCTTTTCTGGTTGGCTCCAGCGAGGCACTCGAGGATCGCTATA
ACTTTATGAAGTTTATGGTGTTCCAGTGGCTGATTGGCGCAACCGATGGCCACGCCAAAAACTTCTCGATTTTCCTCCAG
CCGGGCGGCAGCTACCGCTTAACCCCGTTCTACGACATTATCTCCGCGTTTCCGCTGCTTGGCGGAAAGGGACTGCACCT
GAGCGATCTCAAGCTGTCGATGAGTCTGAAGGCCAGTAAAGGACGTAAAACGGAGATCCAGACGCTCTATCCGCGTCACT
TTCTCGCCACGGCTAAAGAGGTAGGGTTTGCCCAACAGCAGATGCTGGAGATTCTGCGCTATTTTGTCGATAACGTTCCC
CGCGCGGTTGAGGCGGTAAAGGGGACTTTACCGCCTGACTTTTCACAACCGGTATATGAGGCGATCACCGATCGCTTACT
GTGGGTCCATTCACGCTTGCAGAACGCAATGGCGGCGTCTCCGTCGGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT47849 WP_032717448.1 NZ_CP008886:2552545-2552817 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp

>AT47849 NZ_CP008886:2552545-2552817 [Raoultella ornithinolytica]
ATGAGCCCTTCACCAACGATATACAGCCCGGTTCAGCTGGCAAACTATCTCAAGCTGGTGCGCCAGAAAAACCAGTGGAC
GCAGAGCGAGCTGGCTCAGCGTATGGGGATTAAACAGGCCACCGTCTCTAACTTTGAAAATCATCCCGAGAAAACGACGT
TAACCACGGTGTTTAAAATTTTACAGTCACTGGAACTGTCGATGGCGATTTGCGAAAAAAATGCGCCGGATACCGACGAT
AACCGTGATAACCCGCGGGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References