Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4479747..4481094 Replicon chromosome
Accession NZ_CP008873
Organism Pseudomonas aeruginosa strain F9670

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HW11_RS20795 Protein ID WP_144443040.1
Coordinates 4479747..4480451 (-) Length 235 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HW11_RS20800 Protein ID WP_003088112.1
Coordinates 4480540..4481094 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW11_RS20780 4475151..4476428 + 1278 WP_003102743.1 TolC family protein -
HW11_RS20785 4476418..4478589 + 2172 WP_016851733.1 type I secretion system permease/ATPase -
HW11_RS20790 4478579..4479766 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HW11_RS20795 4479747..4480451 - 705 WP_144443040.1 HD domain-containing protein Toxin
HW11_RS20800 4480540..4481094 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HW11_RS20805 4481252..4483447 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HW11_RS20810 4483452..4483913 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
HW11_RS20815 4484244..4484567 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HW11_RS20820 4484580..4484978 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HW11_RS20825 4484975..4485526 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-167)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 235 a.a.        Molecular weight: 26359.65 Da        Isoelectric Point: 6.4112

>T47839 WP_144443040.1 NZ_CP008873:c4480451-4479747 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTDSASQFGATPSVRPPGQRYQRHRLRSSPWLQGSGWHVSTDRACPARLSKGAP

Download         Length: 705 bp

>T47839 NZ_CP008873:c4480451-4479747 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCT
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
TCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGTTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCGACAGCGCCTCGCA
GTTCGGCGCGACGCCTAGCGTGCGCCCGCCCGGGCAGCGTTACCAGCGCCACCGCCTACGTAGCTCGCCATGGCTACAGG
GAAGCGGCTGGCACGTTTCCACCGACCGGGCCTGTCCTGCACGCCTCAGTAAAGGCGCGCCTTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT47839 WP_003088112.1 NZ_CP008873:c4481094-4480540 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT47839 NZ_CP008873:c4481094-4480540 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAATCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References