Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 3161935..3162830 Replicon chromosome
Accession NZ_CP008873
Organism Pseudomonas aeruginosa strain F9670

Toxin (Protein)


Gene name slvT Uniprot ID A0A318E8F0
Locus tag HW11_RS14610 Protein ID WP_023093160.1
Coordinates 3162303..3162830 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A318DY98
Locus tag HW11_RS14605 Protein ID WP_023093161.1
Coordinates 3161935..3162306 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW11_RS14575 3157043..3157261 + 219 WP_016446183.1 AlpA family transcriptional regulator -
HW11_RS14580 3157302..3158168 + 867 WP_023093165.1 ParA family protein -
HW11_RS14585 3158152..3158388 + 237 WP_012584779.1 hypothetical protein -
HW11_RS14590 3158381..3160039 + 1659 WP_023093164.1 ParB family protein -
HW11_RS14595 3160057..3160617 + 561 WP_023093163.1 DUF2857 domain-containing protein -
HW11_RS14600 3160621..3161814 + 1194 WP_023093162.1 hypothetical protein -
HW11_RS14605 3161935..3162306 + 372 WP_023093161.1 hypothetical protein Antitoxin
HW11_RS14610 3162303..3162830 + 528 WP_023093160.1 RES family NAD+ phosphorylase Toxin
HW11_RS14615 3163014..3163802 + 789 WP_023093159.1 TIGR03761 family integrating conjugative element protein -
HW11_RS14620 3163799..3164347 + 549 WP_023093158.1 DUF3158 family protein -
HW11_RS14625 3164344..3164727 + 384 WP_004362284.1 single-stranded DNA-binding protein -
HW11_RS14630 3165022..3167037 + 2016 WP_023093157.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element catB7 - 3109159..3238638 129479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19831.28 Da        Isoelectric Point: 5.2440

>T47837 WP_023093160.1 NZ_CP008873:3162303-3162830 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Download         Length: 528 bp

>T47837 NZ_CP008873:3162303-3162830 [Pseudomonas aeruginosa]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGCGCGCACACCCCGCAGTGGGCCAGCCGGCCAACCAGCGG
CGCTGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGCGACCG
CGCTACGCGAATACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCATTGCGCGAGCTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAACCTTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTTCACATCGAGCCGCCCACTTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13358.05 Da        Isoelectric Point: 6.0705

>AT47837 WP_023093161.1 NZ_CP008873:3161935-3162306 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Download         Length: 372 bp

>AT47837 NZ_CP008873:3161935-3162306 [Pseudomonas aeruginosa]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAGGCCGCGCTTCGTGACCTGATGCGGGTGCTATCGGCCGCCTCGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATCCCGACGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318E8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A318DY98

References