47836

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 3131632..3132240 Replicon chromosome
Accession NZ_CP008873
Organism Pseudomonas aeruginosa strain F9670

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag HW11_RS14460 Protein ID WP_003123043.1
Coordinates 3131893..3132240 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HW11_RS14455 Protein ID WP_003114155.1
Coordinates 3131632..3131883 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW11_RS14430 3126655..3127260 + 606 WP_014603242.1 hypothetical protein -
HW11_RS14435 3127270..3127620 + 351 WP_003159569.1 DUF2523 domain-containing protein -
HW11_RS14440 3127622..3128884 + 1263 WP_023093179.1 hypothetical protein -
HW11_RS14445 3129143..3130435 + 1293 WP_003115206.1 hypothetical protein -
HW11_RS14450 3130435..3131418 + 984 WP_016852062.1 tyrosine-type recombinase/integrase -
HW11_RS14455 3131632..3131883 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HW11_RS14460 3131893..3132240 + 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW11_RS14465 3132550..3133458 - 909 WP_003141085.1 LysR family transcriptional regulator -
HW11_RS14470 3133621..3134721 - 1101 WP_077446928.1 cation transporter -
HW11_RS14475 3134777..3135196 + 420 WP_010791743.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
HW11_RS14480 3135219..3136755 - 1537 Protein_2876 IS66 family transposase -
HW11_RS14485 3136832..3137164 - 333 WP_003121550.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element catB7 - 3109159..3238638 129479
- flank IS/Tn - - 3136832..3137194 362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T47836 WP_003123043.1 NZ_CP008873:3131893-3132240 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T47836 NZ_CP008873:3131893-3132240 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT47836 WP_003114155.1 NZ_CP008873:3131632-3131883 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT47836 NZ_CP008873:3131632-3131883 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References