Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1231535..1232040 Replicon chromosome
Accession NZ_CP008873
Organism Pseudomonas aeruginosa strain F9670

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag HW11_RS05760 Protein ID WP_003121619.1
Coordinates 1231759..1232040 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HW11_RS05755 Protein ID WP_003112628.1
Coordinates 1231535..1231762 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW11_RS05730 1226553..1228046 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
HW11_RS05735 1228215..1229642 + 1428 WP_003083784.1 GABA permease -
HW11_RS05740 1229724..1230065 - 342 WP_003101229.1 alkylphosphonate utilization protein -
HW11_RS05745 1230138..1230638 - 501 WP_003112629.1 LEA type 2 family protein -
HW11_RS05750 1230739..1231359 + 621 WP_003101226.1 hypothetical protein -
HW11_RS05755 1231535..1231762 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HW11_RS05760 1231759..1232040 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
HW11_RS05765 1232340..1233248 + 909 WP_016561475.1 LysR family transcriptional regulator -
HW11_RS05770 1233280..1233666 - 387 WP_014602345.1 aegerolysin family protein -
HW11_RS05775 1233870..1234604 - 735 WP_003117208.1 GntR family transcriptional regulator -
HW11_RS05780 1234705..1235391 - 687 WP_003083762.1 FadR family transcriptional regulator -
HW11_RS05785 1235440..1236789 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T47833 WP_003121619.1 NZ_CP008873:1231759-1232040 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47833 NZ_CP008873:1231759-1232040 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT47833 WP_003112628.1 NZ_CP008873:1231535-1231762 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT47833 NZ_CP008873:1231535-1231762 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References