Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1306185..1306855 Replicon chromosome
Accession NZ_CP008871
Organism Pseudomonas aeruginosa strain W45909

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV96_RS06250 Protein ID WP_023114647.1
Coordinates 1306436..1306855 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV96_RS06245 Protein ID WP_023114648.1
Coordinates 1306185..1306439 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV96_RS06225 1301726..1302727 - 1002 WP_031637439.1 hypothetical protein -
HV96_RS06230 1302812..1303036 + 225 WP_023114650.1 AlpA family phage regulatory protein -
HV96_RS06235 1303039..1303932 + 894 WP_031637438.1 helicase RepA family protein -
HV96_RS06240 1303913..1304890 + 978 WP_031637437.1 plasmid replication -
HV96_RS06245 1306185..1306439 + 255 WP_023114648.1 Arc family DNA-binding protein Antitoxin
HV96_RS06250 1306436..1306855 + 420 WP_023114647.1 type II toxin-antitoxin system VapC family toxin Toxin
HV96_RS06255 1307011..1307781 + 771 WP_023114646.1 P-type conjugative transfer protein TrbJ -
HV96_RS32675 1307795..1307953 + 159 WP_023114645.1 hypothetical protein -
HV96_RS06260 1307955..1309427 + 1473 WP_023114644.1 P-type conjugative transfer protein TrbL -
HV96_RS06265 1309496..1309738 + 243 WP_023114643.1 type I toxin-antitoxin system ptaRNA1 family toxin -
HV96_RS06270 1309750..1310034 + 285 WP_023114642.1 hypothetical protein -
HV96_RS06275 1310037..1310405 + 369 WP_023114641.1 conjugal transfer transcriptional regulator TraJ -
HV96_RS06280 1310444..1310902 - 459 WP_023114640.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1301726..1318634 16908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14925.16 Da        Isoelectric Point: 5.1890

>T47821 WP_023114647.1 NZ_CP008871:1306436-1306855 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T47821 NZ_CP008871:1306436-1306855 [Pseudomonas aeruginosa]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGTGGAAACCCTCTACCTGTCCAGCGTGACGCTGGCCGAGCTGCTGTTCGGCATCGGCGCGCTTCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAGCTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCCATTATGCCGAGCTTGCGGTGAAGGCCCGCACAGCCGGAAAGGGTTTCCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTTGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.87 Da        Isoelectric Point: 6.4760

>AT47821 WP_023114648.1 NZ_CP008871:1306185-1306439 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT47821 NZ_CP008871:1306185-1306439 [Pseudomonas aeruginosa]
ATGGCAATCCTGACAGTGCGGAATGTGCCGGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTGCGCGAGATTCTGGAAAGTGCAGTGAAGTCGGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCGCGTAGGGCTGACAAACGACGACTTCGCAGTATTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References