Detailed information of TA system TA047820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 148626..149131
• Replicon: chromosome
• Accession: NZ_CP008871
• Organism: Pseudomonas aeruginosa strain W45909

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HV96_RS00670
• Protein ID: WP_023114790.1
• Coordinates: 148626..148907 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HV96_RS00675
• Protein ID: WP_003083775.1
• Coordinates: 148904..149131 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV96_RS00645	143877..145226	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
HV96_RS00650	145275..145961	+	687	WP_003083762.1	FadR family transcriptional regulator	-
HV96_RS00655	146062..146796	+	735	WP_003117208.1	GntR family transcriptional regulator	-
HV96_RS00660	147000..147386	+	387	WP_014602345.1	aegerolysin family protein	-
HV96_RS00665	147418..148326	-	909	WP_003083769.1	LysR family transcriptional regulator	-
HV96_RS00670	148626..148907	-	282	WP_023114790.1	type II toxin-antitoxin system toxin ParE	Toxin
HV96_RS00675	148904..149131	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HV96_RS00680	149307..149927	-	621	WP_003101226.1	hypothetical protein	-
HV96_RS00685	150028..150528	+	501	WP_003101228.1	LEA type 2 family protein	-
HV96_RS00690	150601..150942	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
HV96_RS00695	151024..152451	-	1428	WP_003083784.1	GABA permease	-
HV96_RS00700	152620..154113	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10464.21 Da
• Isoelectric Point: 10.0014

>T47820 WP_023114790.1 NZ_CP008871:c148907-148626 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Nucleotide

• Length: 282 bp

>T47820 NZ_CP008871:c148907-148626 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAAGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT47820 WP_003083775.1 NZ_CP008871:c149131-148904 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT47820 NZ_CP008871:c149131-148904 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9