Detailed information of TA system TA047813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 739277..739914
• Replicon: chromosome
• Accession: NZ_CP008870
• Organism: Pseudomonas aeruginosa strain W36662

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HV97_RS03485
• Protein ID: WP_019725766.1
• Coordinates: 739277..739459 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HV97_RS03490
• Protein ID: WP_019725767.1
• Coordinates: 739492..739914 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV97_RS03465	734725..735714	-	990	WP_017001537.1	Abi family protein	-
HV97_RS03470	735980..737455	-	1476	WP_017001536.1	N-6 DNA methylase	-
HV97_RS03475	737448..738029	-	582	WP_017001535.1	restriction endonuclease subunit S	-
HV97_RS03480	738237..738623	-	387	WP_100214074.1	hypothetical protein	-
HV97_RS03485	739277..739459	+	183	WP_019725766.1	type II toxin-antitoxin system HicA family toxin	Toxin
HV97_RS03490	739492..739914	+	423	WP_019725767.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HV97_RS03495	740160..741131	-	972	WP_059309252.1	hypothetical protein	-
HV97_RS03500	741116..741808	-	693	WP_031633726.1	hypothetical protein	-
HV97_RS03505	741805..742347	-	543	WP_059309253.1	hypothetical protein	-
HV97_RS03510	742344..743267	-	924	WP_031633727.1	hypothetical protein	-
HV97_RS03515	743264..743740	-	477	WP_059309254.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	733136..789273	56137

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-62)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6970.07 Da
• Isoelectric Point: 10.2954

>T47813 WP_019725766.1 NZ_CP008870:739277-739459 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Nucleotide

• Length: 183 bp

>T47813 NZ_CP008870:739277-739459 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
TTACTACGGCGACAACCAGACGATCTTCCCCGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 14970.22 Da
• Isoelectric Point: 4.9047

>AT47813 WP_019725767.1 NZ_CP008870:739492-739914 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Nucleotide

• Length: 423 bp

>AT47813 NZ_CP008870:739492-739914 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCTGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGC
GGCAGTCGATCCCGCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTTCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA