Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 739277..739914 Replicon chromosome
Accession NZ_CP008870
Organism Pseudomonas aeruginosa strain W36662

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HV97_RS03485 Protein ID WP_019725766.1
Coordinates 739277..739459 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV97_RS03490 Protein ID WP_019725767.1
Coordinates 739492..739914 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV97_RS03465 734725..735714 - 990 WP_017001537.1 Abi family protein -
HV97_RS03470 735980..737455 - 1476 WP_017001536.1 N-6 DNA methylase -
HV97_RS03475 737448..738029 - 582 WP_017001535.1 restriction endonuclease subunit S -
HV97_RS03480 738237..738623 - 387 WP_100214074.1 hypothetical protein -
HV97_RS03485 739277..739459 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
HV97_RS03490 739492..739914 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV97_RS03495 740160..741131 - 972 WP_059309252.1 hypothetical protein -
HV97_RS03500 741116..741808 - 693 WP_031633726.1 hypothetical protein -
HV97_RS03505 741805..742347 - 543 WP_059309253.1 hypothetical protein -
HV97_RS03510 742344..743267 - 924 WP_031633727.1 hypothetical protein -
HV97_RS03515 743264..743740 - 477 WP_059309254.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 733136..789273 56137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T47813 WP_019725766.1 NZ_CP008870:739277-739459 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

>T47813 NZ_CP008870:739277-739459 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
TTACTACGGCGACAACCAGACGATCTTCCCCGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT47813 WP_019725767.1 NZ_CP008870:739492-739914 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp

>AT47813 NZ_CP008870:739492-739914 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCTGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGC
GGCAGTCGATCCCGCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTTCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References