Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 201379..201884 Replicon chromosome
Accession NZ_CP008870
Organism Pseudomonas aeruginosa strain W36662

Toxin (Protein)


Gene name parE Uniprot ID A0A7M2ZNP4
Locus tag HV97_RS00935 Protein ID WP_009875660.1
Coordinates 201379..201660 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag HV97_RS00940 Protein ID WP_003137009.1
Coordinates 201657..201884 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV97_RS00910 196630..197979 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HV97_RS00915 198028..198714 + 687 WP_004351997.1 FadR family transcriptional regulator -
HV97_RS00920 198815..199549 + 735 WP_003117208.1 GntR family transcriptional regulator -
HV97_RS00925 199753..200139 + 387 WP_014602345.1 aegerolysin family protein -
HV97_RS00930 200171..201079 - 909 WP_003083769.1 LysR family transcriptional regulator -
HV97_RS00935 201379..201660 - 282 WP_009875660.1 type II toxin-antitoxin system toxin ParE Toxin
HV97_RS00940 201657..201884 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
HV97_RS00945 202060..202680 - 621 WP_023086863.1 hypothetical protein -
HV97_RS00950 202781..203281 + 501 WP_003101228.1 LEA type 2 family protein -
HV97_RS00955 203354..203695 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HV97_RS00960 203777..205204 - 1428 WP_003083784.1 GABA permease -
HV97_RS00965 205373..206866 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10461.25 Da        Isoelectric Point: 10.4670

>T47812 WP_009875660.1 NZ_CP008870:c201660-201379 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLKRWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47812 NZ_CP008870:c201660-201379 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGAAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT47812 WP_003137009.1 NZ_CP008870:c201884-201657 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT47812 NZ_CP008870:c201884-201657 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCGGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2ZNP4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References