47797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2631017..2631522 Replicon chromosome
Accession NZ_CP008867
Organism Pseudomonas aeruginosa strain T52373

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HW00_RS12065 Protein ID WP_003083773.1
Coordinates 2631017..2631298 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HW00_RS12070 Protein ID WP_003083775.1
Coordinates 2631295..2631522 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW00_RS12040 2626268..2627617 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HW00_RS12045 2627666..2628352 + 687 WP_003083762.1 FadR family transcriptional regulator -
HW00_RS12050 2628453..2629187 + 735 WP_003117208.1 GntR family transcriptional regulator -
HW00_RS12055 2629391..2629777 + 387 WP_014602345.1 aegerolysin family protein -
HW00_RS12060 2629809..2630717 - 909 WP_003083769.1 LysR family transcriptional regulator -
HW00_RS12065 2631017..2631298 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HW00_RS12070 2631295..2631522 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HW00_RS12075 2631698..2632318 - 621 WP_003101226.1 hypothetical protein -
HW00_RS12080 2632419..2632919 + 501 WP_031800112.1 LEA type 2 family protein -
HW00_RS12085 2632992..2633333 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HW00_RS12090 2633415..2634842 - 1428 WP_003083784.1 GABA permease -
HW00_RS12095 2635011..2636504 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T47797 WP_003083773.1 NZ_CP008867:c2631298-2631017 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47797 NZ_CP008867:c2631298-2631017 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT47797 WP_003083775.1 NZ_CP008867:c2631522-2631295 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT47797 NZ_CP008867:c2631522-2631295 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References