47791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5047179..5047787 Replicon chromosome
Accession NZ_CP008866
Organism Pseudomonas aeruginosa strain T38079

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag HW01_RS23915 Protein ID WP_003123043.1
Coordinates 5047179..5047526 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HW01_RS23920 Protein ID WP_003114155.1
Coordinates 5047536..5047787 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW01_RS23890 5042256..5042588 + 333 WP_003121550.1 IS66 family insertion sequence element accessory protein TnpB -
HW01_RS23895 5042665..5044201 + 1537 Protein_4625 IS66 family transposase -
HW01_RS23900 5044224..5044643 - 420 WP_010791743.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
HW01_RS23905 5044699..5045799 + 1101 WP_077446928.1 cation transporter -
HW01_RS23910 5045962..5046870 + 909 WP_003141085.1 LysR family transcriptional regulator -
HW01_RS23915 5047179..5047526 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW01_RS23920 5047536..5047787 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HW01_RS23925 5048001..5048984 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
HW01_RS23930 5048984..5050276 - 1293 WP_003115206.1 hypothetical protein -
HW01_RS23935 5050535..5051797 - 1263 WP_023093179.1 hypothetical protein -
HW01_RS23940 5051799..5052149 - 351 WP_003159569.1 DUF2523 domain-containing protein -
HW01_RS23945 5052159..5052764 - 606 WP_014603242.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4938483..5059110 120627
- flank IS/Tn - - 5042226..5042588 362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T47791 WP_003123043.1 NZ_CP008866:c5047526-5047179 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T47791 NZ_CP008866:c5047526-5047179 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT47791 WP_003114155.1 NZ_CP008866:c5047787-5047536 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT47791 NZ_CP008866:c5047787-5047536 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References