Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 5016589..5017484 Replicon chromosome
Accession NZ_CP008866
Organism Pseudomonas aeruginosa strain T38079

Toxin (Protein)


Gene name slvT Uniprot ID A0A318E8F0
Locus tag HW01_RS23760 Protein ID WP_023093160.1
Coordinates 5016589..5017116 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A318DY98
Locus tag HW01_RS23765 Protein ID WP_023093161.1
Coordinates 5017113..5017484 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW01_RS23740 5012382..5014397 - 2016 WP_023093157.1 DNA topoisomerase III -
HW01_RS23745 5014692..5015075 - 384 WP_004362284.1 single-stranded DNA-binding protein -
HW01_RS23750 5015072..5015620 - 549 WP_023093158.1 DUF3158 family protein -
HW01_RS23755 5015617..5016405 - 789 WP_023093159.1 TIGR03761 family integrating conjugative element protein -
HW01_RS23760 5016589..5017116 - 528 WP_023093160.1 RES family NAD+ phosphorylase Toxin
HW01_RS23765 5017113..5017484 - 372 WP_023093161.1 hypothetical protein Antitoxin
HW01_RS23770 5017605..5018798 - 1194 WP_023093162.1 hypothetical protein -
HW01_RS23775 5018802..5019362 - 561 WP_023093163.1 DUF2857 domain-containing protein -
HW01_RS23780 5019380..5021038 - 1659 WP_023093164.1 ParB family protein -
HW01_RS23785 5021031..5021267 - 237 WP_012584779.1 hypothetical protein -
HW01_RS23790 5021251..5022117 - 867 WP_023093165.1 ParA family protein -
HW01_RS23795 5022158..5022376 - 219 WP_016446183.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4938483..5059110 120627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19831.28 Da        Isoelectric Point: 5.2440

>T47790 WP_023093160.1 NZ_CP008866:c5017116-5016589 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Download         Length: 528 bp

>T47790 NZ_CP008866:c5017116-5016589 [Pseudomonas aeruginosa]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGCGCGCACACCCCGCAGTGGGCCAGCCGGCCAACCAGCGG
CGCTGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGCGACCG
CGCTACGCGAATACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCATTGCGCGAGCTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAACCTTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTTCACATCGAGCCGCCCACTTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13358.05 Da        Isoelectric Point: 6.0705

>AT47790 WP_023093161.1 NZ_CP008866:c5017484-5017113 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Download         Length: 372 bp

>AT47790 NZ_CP008866:c5017484-5017113 [Pseudomonas aeruginosa]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAGGCCGCGCTTCGTGACCTGATGCGGGTGCTATCGGCCGCCTCGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATCCCGACGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318E8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A318DY98

References