Detailed information of TA system TA047790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 5016589..5017484
• Replicon: chromosome
• Accession: NZ_CP008866
• Organism: Pseudomonas aeruginosa strain T38079

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A318E8F0
• Locus tag: HW01_RS23760
• Protein ID: WP_023093160.1
• Coordinates: 5016589..5017116 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A318DY98
• Locus tag: HW01_RS23765
• Protein ID: WP_023093161.1
• Coordinates: 5017113..5017484 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW01_RS23740	5012382..5014397	-	2016	WP_023093157.1	DNA topoisomerase III	-
HW01_RS23745	5014692..5015075	-	384	WP_004362284.1	single-stranded DNA-binding protein	-
HW01_RS23750	5015072..5015620	-	549	WP_023093158.1	DUF3158 family protein	-
HW01_RS23755	5015617..5016405	-	789	WP_023093159.1	TIGR03761 family integrating conjugative element protein	-
HW01_RS23760	5016589..5017116	-	528	WP_023093160.1	RES family NAD+ phosphorylase	Toxin
HW01_RS23765	5017113..5017484	-	372	WP_023093161.1	hypothetical protein	Antitoxin
HW01_RS23770	5017605..5018798	-	1194	WP_023093162.1	hypothetical protein	-
HW01_RS23775	5018802..5019362	-	561	WP_023093163.1	DUF2857 domain-containing protein	-
HW01_RS23780	5019380..5021038	-	1659	WP_023093164.1	ParB family protein	-
HW01_RS23785	5021031..5021267	-	237	WP_012584779.1	hypothetical protein	-
HW01_RS23790	5021251..5022117	-	867	WP_023093165.1	ParA family protein	-
HW01_RS23795	5022158..5022376	-	219	WP_016446183.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4938483..5059110	120627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19831.28 Da
• Isoelectric Point: 5.2440

>T47790 WP_023093160.1 NZ_CP008866:c5017116-5016589 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Nucleotide

• Length: 528 bp

>T47790 NZ_CP008866:c5017116-5016589 [Pseudomonas aeruginosa]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGCGCGCACACCCCGCAGTGGGCCAGCCGGCCAACCAGCGG
CGCTGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGCGACCG
CGCTACGCGAATACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCATTGCGCGAGCTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAACCTTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTTCACATCGAGCCGCCCACTTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13358.05 Da
• Isoelectric Point: 6.0705

>AT47790 WP_023093161.1 NZ_CP008866:c5017484-5017113 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Nucleotide

• Length: 372 bp

>AT47790 NZ_CP008866:c5017484-5017113 [Pseudomonas aeruginosa]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAGGCCGCGCTTCGTGACCTGATGCGGGTGCTATCGGCCGCCTCGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATCCCGACGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Structures

Toxin

• AlphaFold DB: A0A318E8F0

Antitoxin

• AlphaFold DB: A0A318DY98