47782

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5200315..5200923 Replicon chromosome
Accession NZ_CP008865
Organism Pseudomonas aeruginosa strain S86968

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag HW02_RS24915 Protein ID WP_003123043.1
Coordinates 5200315..5200662 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HW02_RS24920 Protein ID WP_003114155.1
Coordinates 5200672..5200923 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW02_RS24890 5195391..5195723 + 333 WP_003121550.1 IS66 family insertion sequence element accessory protein TnpB -
HW02_RS24895 5195800..5197336 + 1537 Protein_4819 IS66 family transposase -
HW02_RS24900 5197359..5197778 - 420 WP_010791743.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
HW02_RS24905 5197834..5198934 + 1101 WP_077446928.1 cation transporter -
HW02_RS24910 5199097..5200005 + 909 WP_003141085.1 LysR family transcriptional regulator -
HW02_RS24915 5200315..5200662 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW02_RS24920 5200672..5200923 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HW02_RS24925 5201137..5202120 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
HW02_RS24930 5202120..5203412 - 1293 WP_003115206.1 hypothetical protein -
HW02_RS24935 5203671..5204933 - 1263 WP_023093179.1 hypothetical protein -
HW02_RS24940 5204935..5205285 - 351 WP_003159569.1 DUF2523 domain-containing protein -
HW02_RS24945 5205295..5205900 - 606 WP_014603242.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5091614..5212245 120631
- flank IS/Tn - - 5195361..5195723 362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T47782 WP_003123043.1 NZ_CP008865:c5200662-5200315 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T47782 NZ_CP008865:c5200662-5200315 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT47782 WP_003114155.1 NZ_CP008865:c5200923-5200672 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT47782 NZ_CP008865:c5200923-5200672 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References